ABSTRACT.The reliability analysis applied to viscoelastic and orthotropic materials, in the case of mixed mode configuration, is studied in this work. The M integral, separating mixed mode during creep crack initiation in viscoelastic field, is used in the analytical approach. The main development, based on conservative law, and a combination of real and virtual displacement fields, is proposed. In order to provide mixed mode configuration, a Compact Tension Shear (CTS) specimen is used in the numerical process. Simultaneously the fracture and the viscoelastic procedures are coupled with reliability analysis in order to take account for model and parameter uncertainties. In this case, the random parameters related to model factors, elastic constants are defined in the reliability analysis of time dependent fracture materials subjected to complex loading. As results, the reliability levels are computed and discussed according to various mixed-mode loading scenarios