REBa2Cu3O7‐x (REBCO) exhibits outstanding qualities such as a high irreversible field (7 T) and strong current‐carrying capacity (77 K, 106 A cm−2), making it ideal for high magnetic field applications such as fusion, accelerators, and nuclear magnetic resonance. However, the degradation of in‐field critical current density (Jc) due to vortex motion is a significant hurdle. Research indicates that improving vortex pinning can notably enhance Jc in REBCO, showing promise for its future high‐field applications. This review explores vortex pinning mechanisms, artificial pinning centers (APCs), and how environmental conditions affect pinning characteristics, highlighting advancements in vortex pinning for REBCO in magnetic fields. Different methods for introducing APCs are discussed and compared for evaluating their efficacy in achieving optimal nanoparticle distributions and consequent superconducting performance improvements, underscoring the importance of nano‐defect features (type, size, and distribution) in optimizing the superconducting properties of the REBCO. Additionally, the review tackles current challenges, shares recent research breakthroughs, and outlines future research directions for designing pinning landscapes to further improve REBCO performance.