Mixed Quaternary Ammonium and Phosphonium Salts Bound to Macromolecular Supports for Removal Bacteria from Water

Popa, Adriana; Ilia, Gheorghe; Iliescu, Smaranda; Dehelean, Gheorghe; Pascariu, Aurelia; Bora, Alina; Davidescu, Corneliu Mircea

doi:10.1080/15421400490479280

Cited by 18 publications

(15 citation statements)

References 9 publications

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“…17-21 Popa et al 22,23 reported the synthesis of quaternary ammonium and phosphonium salts grafted on cross-linked polymer-supports and their application as antibacterial agents for removal of bacteria from water. Although several types of soluble and insoluble antibacterial monoquats were reported, they suffer from lower activity and irritant side effects because of the availability of a single quaternary ammonium group.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of novel insoluble bead‐shaped polymer‐supported multiquaternary ammonium salts

Murugan

Gopinath

Shanmugayya

et al. 2010

J of Applied Polymer Sci

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This study describes the effect of antibacterial activity of newly reported five different novel insoluble bead-shaped polymer-supported multiquaternary ammonium salts (PM quats) viz., bis-quat, tris-quat (2 Nos.), tetrakis-quat, hexakis-quat containing two, three, four, and six quaternary ammonium groups, respectively. The presence of number of quaternary ammonium groups in each salt was established already through Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and chloride ion analyzes. The antibacterial activities of these five different PM quats against three different bacteria viz., Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa were investigated by serial dilution and spread plate method and compared the same with a monoquat containing single quaternary ammonium group. The extent of antibacterial activity has been measured in terms of colony forming units (CFU) at different time intervals. The observed results show that all the PM quats exhibited excellent-antibacterial activity against each bacterium. On the basis of the CFU values, the antibacterial activity was found to increase from bis-quat to hexakis-quat, which reveals that the activity of PM quats increases with increase in the number of quaternary ammonium groups. The mechanism of interaction of quats with bacterial cytoplasmic membrane has been explained as an adsorption-like phenomenon. The reusability of highly active hexakis-quat against Staphylococcus aureus was studied and the activity was found to reduce after first cycle.

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Section: Introductionmentioning

confidence: 99%

Antibacterial activity of novel insoluble bead‐shaped polymer‐supported multiquaternary ammonium salts

Murugan

Gopinath

Shanmugayya

et al. 2010

J of Applied Polymer Sci

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“…1) are effective coatings for commercial water filtration membranes that resist protein adsorption under static exposure and dynamic flow conditions. Phosphonium-and ammonium-functionalized polymers have previously been used as biocides to remove bacteria and living organisms from surfaces [46,47]; however, they have not been studied for resisting non-specific protein adsorption. Only one example of a tetra(alkyl)ammonium-functionalized SAM has been previously explored for protein resistance and exhibited only mediocre results [29].…”

Section: Introductionmentioning

confidence: 99%

New protein-resistant coatings for water filtration membranes based on quaternary ammonium and phosphonium polymers

Hatakeyama

Gabriel

et al. 2009

Journal of Membrane Science

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“…FTIR spectra of he obtained mixed ammonium and phosphonium resins [37] shown the presence of mixed ammonium and phosphonium groups on the surface of styrene-divinylbenzen copolymer support. The decrease in the intensity of the chloromethyl absorption bands at 1260 cm -1 and 1430 cm -1 suggests that a direct quaternization of the residual chloromethyl groups of the initial copolymer also took place, along with the main reaction of transquaternization of the quaternary ammonium groups.…”

Section: Resultsmentioning

confidence: 98%

“…Mixed ammonium and phosphonium salts grafted on a styrene -7 % divinylbenzene copolymer (Scheme 2) were obtained by Michaelis-Becker polymer analogue reaction [37].…”

Section: Functionalization Of Macromolecular Supports With Phosphonatmentioning

confidence: 99%

Effect of polymer support functionalization on enzyme immobilization and catalytic activity

Pârvulescu

Popa

Păun

et al. 2014

Pure and Applied Chemistry

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Two enzymes, laccase and peroxidase, were immobilized on chloromethylated styrene-divinylbenzene copolymers supports functionalized with phosphonates ((RO) 2 PO) or mixed ammonium and phosphonium groups (N + R 3 Cl -, P + Ph 3 Cl -). Phosphonates groups and quaternary ammonium salts were grafted on the "gel-type" copolymer by Michaelis-Becker polymer analogue reaction. Mixed polymer-supported ammonium and phosphonium salts were obtained by transquaternization of the ammonium groups to phosphonium group. The degrees of functionalization for obtained polymers were relatively high ensuring a sufficient concentration of active centers per unit mass of the copolymer. The obtained materials were characterized by thermal analysis, FTIR spectroscopy and SEM microscopy. The effects of OR1 and R2 radicals from phosphonate and respectively ammonium groups, as well as those of glutaraldehyde utilization on the immobilization yield and the catalytic properties of the supported enzymes were indicated. The activity of enzymes increased after immobilization and high immobilization yield was obtained for all the samples. The higher interaction of enzymes with support was indicated for mixed ammonium and phosphonium functions. A higher catalytic activity was obtained for peroxidase in oxidation of phenol and laccase in oxidation of anisole. The low effect of glutaraldehyde on enzyme activity reveals the strong interaction of enzyme with the polymer support, respectively with the functional groups.

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Mixed Quaternary Ammonium and Phosphonium Salts Bound to Macromolecular Supports for Removal Bacteria from Water

Cited by 18 publications

References 9 publications

Antibacterial activity of novel insoluble bead‐shaped polymer‐supported multiquaternary ammonium salts

Antibacterial activity of novel insoluble bead‐shaped polymer‐supported multiquaternary ammonium salts

New protein-resistant coatings for water filtration membranes based on quaternary ammonium and phosphonium polymers

Effect of polymer support functionalization on enzyme immobilization and catalytic activity

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