Mixed Solvent Method for Improving the Size Uniformity and Cargo-Loading Efficiency of ZIF-8 Nanoparticles

Guo, Heze; Liu, Lingshan; Hu, Qiangqiang; Dou, Hongjing

doi:10.1021/acs.langmuir.1c01399

Cited by 7 publications

(10 citation statements)

References 55 publications

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“…Meanwhile, in the water/DMSO system, more DTX was encapsulated than in methanol or water. 52 The above results show that DTX can be efficiently loaded into the nanoparticles. Furthermore, the stability of DTX@ZIF-8 and RVG 15 -PEG@DTX@ZIF-8 in water was evaluated after storage for 7 d at 4 °C.…”

Section: Resultsmentioning

confidence: 72%

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Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model

Wu¹,

Liu²,

Chen³

et al. 2022

IJN

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Introduction The blood–brain barrier (BBB) is a key obstacle to the delivery of drugs into the brain. Therefore, it is essential to develop an advanced drug delivery nanoplatform to solve this problem. We previously screened a small rabies virus glycoprotein 15 (RVG 15 ) peptide with 15 amino acids and observed that most of the RVG 15 -modified nanoparticles entered the brain within 1 h of administration. The high BBB penetrability gives RVG 15 great potential for brain-targeted drug delivery systems. Moreover, a multifunctional integrated nanoplatform with a high drug-loading capacity, tunable functionality, and controlled drug release is crucial for tumor treatment. Zeolitic imidazolate framework (ZIF-8) is a promising nanodrug delivery system. Methods Inspired by the biomimetic concept, we designed RVG 15 -coated biomimetic ZIF-8 nanoparticles (RVG 15 -PEG@DTX@ZIF-8) for docetaxel (DTX) delivery to achieve efficient glioblastoma elimination in mice. This bionic nanotherapeutic system was prepared by one-pot encapsulation, followed by coating with RVG 15 -PEG conjugates. The size, morphology, stability, drug-loading capacity, and release of RVG 15 -PEG@DTX@ZIF-8 were thoroughly investigated. Additionally, we performed in vitro evaluation, cell uptake capacity, BBB penetration, and anti-migratory ability. We also conducted an in vivo evaluation of the biodistribution and anti-glioma efficacy of this bionic nanotherapeutic system in a mouse mode. Results In vitro studies showed that, this bionic nanotherapeutic system exhibited excellent targeting efficiency and safety in HBMECs and C6 cells and high efficiency in crossing the BBB. Furthermore, the nanoparticles cause rapid DTX accumulation in the brain, allowing deeper penetration into glioma tumors. In vivo antitumor assay results indicated that RVG 15 -PEG@DTX@ZIF-8 significantly inhibited glioma growth and metastasis, thereby improving the survival of tumor-bearing mice. Conclusion Our study demonstrates that our bionic nanotherapeutic system using RVG 15 peptides is a promising and powerful tool for crossing the BBB and treating glioblastoma.

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Section: Resultsmentioning

confidence: 72%

“…DTX@ZIF-8 nanoparticles were prepared using a simple one-pot synthesis as described in previous reports, with some modifications. 52 In detail, 5 mg of DTX (Meilun, China) and 80 mg of Zn(NO 3 ) 2 ·6H 2 O (Macklin, China) were dissolved in 3 mL of DMSO. The mixture was then stirred for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model

Wu¹,

Liu²,

Chen³

et al. 2022

IJN

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“…This detection strategy relied on the incubation of cell lines with fluorescent ZIF-8 (FZIF-8) nanoparticles and the subsequent flow cytometry analysis of these cells based on the hypothesis that the FZIF-8 nanoparticles would display a specific fluorescent response in DR cancer cells that could be readily distinguished from that in DS cancer cells (Scheme C). Briefly, the FZIF-8 nanoparticles were prepared via the method described in our previous work, , and they exhibited a polyhedral morphology with a diameter of ∼123 nm (Figure S1A,B). The hydrodynamic diameter measured by dynamic light scattering (DLS) was about 143 nm (size polydispersity index (PDI) = 0.212), which reflects the excellent dispersity of FZIF-8 nanoparticles in water (Figure S1C).…”

Section: Resultsmentioning

confidence: 99%

Multidimensional Quantitative Measurement of Cancer Chemoresistance through Differential ZIF-8 Nanoparticle Cellular Retention

Liu

Cheng

Guo

et al. 2022

ACS Appl. Mater. Interfaces

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Chemoresistance of cancer cells is conventionally quantified by half-maximal inhibitory concentration (IC 50 ) or multidrug resistance gene 1 (MDR1) values, but these metrics can only reflect the overall drug resistance level of a cancer cell line. Meanwhile, the multidimensional evaluation of both the heterogeneity in a cell line and the drug resistance degree of each cell still presents a daunting challenge. We report here that the cellular heterogeneity, cellular cross contamination, and the proportion of chemoresistant cancer cells can be visualized via flow cytometry through the differential cellular retention of fluorescent ZIF-8 nanoparticles. In addition, we show that the degree of drug resistance exhibited by each cell subpopulation can be quantified by differing fluorescence of the drugresistant and drug-sensitive cells in the corresponding flow cytometry profile, and the quantified metric S is highly consistent with the MDR1 expression results. Importantly, this novel strategy is applicable to various cancer cell lines, thus demonstrating a universal diagnosis platform for multidimensional, quantitative, and highly efficient diagnosis of cancer chemoresistance.

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“…Nonetheless, ZIF‐8 synthesized in aqueous systems typically exhibits a lower surface area compared to those prepared in organic systems. In 2021, Guo et al [ 30 ] successfully synthesized ZIF‐8 with exceptional uniformity and regularity using a solvent mixture of dimethyl sulfoxide (DMSO) and water. Furthermore, they decorated these nanoparticles with dextran so as to improve chemical stability and biocompatibility.…”

Section: Synthesis Of Zif‐8mentioning

confidence: 99%

Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Wang,

Wu,

Ren

et al. 2023

Small Methods

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Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability and structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading of nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, the development and recent progress of various synthesis approaches are briefly summarized. In addition, its interesting properties such as adjustable porosity, excellent thermal, and chemical stabilities are introduced. Further, five representative biomedical applications are highlighted based on above physicochemical properties. Finally, the remaining challenges and offered insights into the future outlook are also discussed. This review aims to understand the co‐relationships between structures and biomedical functionalities, offering the opportunity to construct attractive materials with promising characteristics.

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Mixed Solvent Method for Improving the Size Uniformity and Cargo-Loading Efficiency of ZIF-8 Nanoparticles

Cited by 7 publications

References 55 publications

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model

Multidimensional Quantitative Measurement of Cancer Chemoresistance through Differential ZIF-8 Nanoparticle Cellular Retention

Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

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