Mixing in an enclosed microfluidic chamber through moving boundary motions

Yang, Chengpeng; Hu, Dinglong; Sun, Baoce; Cui, Xin; Zhu, Qian; Lam, Raymond H. W.

doi:10.1007/s10404-015-1596-y

Cited by 8 publications

(11 citation statements)

References 51 publications

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“…4). The obtained Young modulus of 760±140 kPa is in good agreement with the results of [14] and [34].…”

Section: Matherials and Methodssupporting

confidence: 88%

“…In general, fluid-structure interaction modelling can only be addressed by numerical simulations [11,12]. The lumped element method is traditionally used to simplify modelling when the pump is analyzed separately from the microfluidic system and its characteristics are taken as boundary conditions for a liquid flow simulation within a microchannel [13,14]. In those cases when the law of motion of actuators is known, the problem reduces to solving the Navier-Stokes equation in a domain with moving boundaries, which can be done both with the help of classical mesh methods of computational hydrodynamics and Stokeslets-meshfree computations [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Modelling and characterization of a pneumatically actuated peristaltic micropump

Gerasimenko

Kindeeva

Петров

et al. 2017

Applied Mathematical Modelling

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There is an emerging class of microfluidic bioreactors which possess long-term, closed circuit perfusion under sterile conditions with in vivo-like flow parameters. Integrated into microfluidics, peristaltic-like pneumatically actuated displacement micropumps are able to meet these requirements. We present both a theoretical and experimental characterization of such pumps. In order to examine volume flow rate, we have developed a mathematical model describing membrane motion under external pressure. The viscoelasticity of the membrane and hydrodynamic resistance of the microfluidic channel have been taken into account. Unlike other models, the developed model includes only the physical parameters of the pump and allows the estimation of their impact on the resulting flow. The model has been validated experimentally.

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“…4). The obtained Young modulus of 760±140 kPa is in good agreement with the results of [14] and [34].…”

Section: Matherials and Methodssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Modelling and characterization of a pneumatically actuated peristaltic micropump

Gerasimenko

Kindeeva

Петров

et al. 2017

Applied Mathematical Modelling

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“…The proposed mixer provides appropriate circulation flow within the culture region in a peristaltic manner, 49 which is critical for long-term cell growth. In addition, it provides a platform for the majority of biochemical analyses that involve liquid handling, i.e., reagents mixing in bioprocesses and bioengineering, 50 long-term cell cultivation, and studies in which cells grow and react with introduced drugs for drug screening/delivery applications 51 .…”

Section: Resultsmentioning

confidence: 99%

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

et al. 2016

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This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

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“…The motion of particles at low Reynolds number is of considerable importance in a great variety of microfluidic applications such as mixing (Lewpiriyawong et al, 2012;Yang et al, 2015;Zhou et al, 2017), particle separation (Kang et al, 2009;Xuan et al, 2010) and transportation (Yap et al, 2007;Nguyen, 2012). The aggregation and collision of particles are affected by the particle-particle interaction which will dominate the hydrodynamic behaviors when the particle concentration is high (Wilson, 2013).…”

Section: Introductionmentioning

confidence: 99%

Slow viscous flow around two particles in a cylinder

Yao

Marcos

Wong

2017

Microfluid Nanofluid

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This article describes the motion of two arbitrarily located free moving particles in a cylindrical tube with background Poiseuille flow at low Reynolds number. We employ the Lamb's general solution based on spherical harmonics and construct a framework based on cylindrical harmonics to solve the flow field around the particles and the flow within the tube, respectively. The two solutions are performed in an iterated framework using the method of reflections. We compute the drag force and torque coefficients of the particles which are dependent on the distances among the cylinder wall and the two particles. In addition, we provide detailed flow field in the vicinity of the two particles including streamlines and velocity contour. Our analysis reveals that the particle-particle interaction can be neglected when the separation distance is three times larger than the sum of particles radii when the two particles are identical. Furthermore, the direction of Poiseuille Flow, the particle position relative to the axis and the particle size can make the two particles attract or repel. Unlike the single particle case, the two particles can move laterally due to the hydrodynamic interaction. Such analysis can give insights to understand the mechanisms of collision and aggregation of particles in microchannels.

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Mixing in an enclosed microfluidic chamber through moving boundary motions

Cited by 8 publications

References 51 publications

Modelling and characterization of a pneumatically actuated peristaltic micropump

Modelling and characterization of a pneumatically actuated peristaltic micropump

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

Slow viscous flow around two particles in a cylinder

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