Mixing of menthol-based hydrophobic deep eutectic solvents as a novel method to tune their properties

Jin, Yan; Jung, Dasom; Li, Ké; Park, Keun-Bae; Lee, Jeongmi

doi:10.1016/j.molliq.2019.112416

Cited by 23 publications

(17 citation statements)

References 44 publications

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“…The polarities of the three bioactive compounds in the sample are relatively weak, so they are suitable for the use of hydrophobic DESs. By changing the molar ratio of the components, the physical and chemical properties of DESs can be changed [ 41 ]. Adjusting the appropriate molar ratio and under the action of ultrasound, the three active compounds can be better extracted into DESs and the components with large polarity difference can be reduced.…”

Section: Resultsmentioning

confidence: 99%

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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Deep eutectic solvents (DESs) are considered as efficient and green solvents for the extraction of bioactive compounds from medicinal plants. In this work, a novel method of DES-based ultrasound-assisted extraction of bioactive compounds from Baphicacanthus cusia leaves (BCL) was established. Systematic screening and the morphology of the original and treated BCL were observed with scanning electron microscopy to determine the extraction efficiency of different solvents. The extraction conditions were optimized by Box–Behnken design (BBD) tests and the optimal extraction conditions were as follows: lactic acid/L-menthol ratio of 5: 2 (mol/mol), solid–liquid ratio of 80.0 mL/g and temperature of 60.5 °C. The extraction yields of tryptanthrin, indigo and indirubin reached 0.356, 1.744 and 0.562 mg/g, respectively. The results of a 2,2-diphenyl-1-picrylhydrazy (DPPH) radical scavenging activity test indicated the feasibility of DESs in the extraction of bioactive compounds. This study indicated that L-menthol/lactic acid was a green and efficient solvent for the extraction of bioactive compounds from BCL, and DES-based ultrasound-assisted extraction could be used as an effective application strategy for the extraction of bioactive compounds from medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Cai

et al. 2021

Molecules

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“…However, Křížek et al have, for the first time, introduced the use of tailor-made hydrophobic DES as extraction media for the isolation of various phytocannabinoids from Cannabis sativa [84]. This is a relatively new field of research and only a few papers have been published up to date [85,86]. Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties.…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

“…Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties. In the both published articles, menthol-based DES were used to isolate the most important phytochemicals from the leaves of the Ginkgo biloba, and properties of DES was tuned by mixing two or more different hydrophobic solvents [85,86]. Cao et al have also published an interesting paper describing the simultaneous extraction of hydrophilic and hydrophobic bioactive compounds from the leaves of Ginkgo biloba [87].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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“…However, Křížek et al (2018) have, for the first time, introduced the use of tailor-made hydrophobic DES as extraction media for the isolation of various phytocannabinoids from Cannabis sativa (Křížek et al, 2018). This is a relatively new field of research and only a few findings have been published on this aspect in the last decade (Jin et al, 2020;Wang, Yang, et al, 2020). Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties.…”

Section: Extraction Of Chitins and Collagenmentioning

confidence: 99%

“…Since hydrophobic DES components are not miscible with water, an alternative method is required to adjust their physical-chemical properties. In two recent findings (Jin et al, 2020;Wang, Yang, et al, 2020), menthol-based DES was used to isolate the most important phytochemicals from the leaves of the Ginkgo biloba, and properties of DES were tuned by mixing two or more different hydrophobic solvents (Jin et al, 2020;Wang, Yang, et al, 2020). Cao et al (2018) have reported simultaneous extraction of hydrophilic and hydrophobic bioactive compounds from the leaves of Ginkgo biloba using the hydrophobic solvent systems.…”

Section: Extraction Of Chitins and Collagenmentioning

confidence: 99%

Deep eutectic solvents: The new generation sustainable and safe extraction systems for bioactive compounds in agri food sector: An update

Saini

Kumar

Sharma

et al. 2021

Food Processing Preservation

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Extraction of functional and bioactive compounds with high volumes, quality, and bioactivity to improve their delivery particularly in food applications has always been a priority in food chemistry. The continuous search for newer, more sophisticated extraction mediums with improved sustainability, extractability, stability, bioactivity, and safety has resulted in the development of deep eutectic solvent (DES) based on the eutectic behavior of various salts. DESs are the mixtures of hydrogen bond donor (HBD) and hydrogen bond acceptor (HBA) with complexing agents having safe biological backgrounds and a promising approach for current innovations in green extraction technologies. Research efforts focused on their utilization as economic extraction mediums with relatively higher environmental and health safety have been growing fast. Significant publication count on DES for various food and pharmaceutical applications to overcome the limitations of conventional solvents has been reported in the last decade. Although, limited work has been carried out on the extraction of bioactive compounds from various biological sources yet the persuasive recognition of these extraction systems has fascinated the consideration of the research community for their investigation. This review focuses primarily on addressing the distinctive qualities of DES especially as extraction medium along with the conventional and neoteric extraction techniques for a wide range of bioactive compounds. The review summarizes the-state-of-the-art application of DESs in the extraction of bioactive compounds their classification, preparation, activity, safety concerns, recent trends, and future perspectives for their potential utilization in the food industry. Novelty impact statement: DES is new generation solvents and based on the material from which they are derived they can be the safest, cheapest, and most effective extraction systems. Extraction efficiency and recycling of both the bioactive compounds and the solvent are significantly improved by using DES. Overall, the extractability, safety, cytotoxicity and ecotoxicity of the novel DESs need extensive research trials and clinical documentation.

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Mixing of menthol-based hydrophobic deep eutectic solvents as a novel method to tune their properties

Cited by 23 publications

References 44 publications

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Optimization of Extraction of Bioactive Compounds from Baphicacanthus cusia Leaves by Hydrophobic Deep Eutectic Solvents

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Deep eutectic solvents: The new generation sustainable and safe extraction systems for bioactive compounds in agri food sector: An update

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