Mixture design approach to optimize the performance of TiO2 modified zirconia/alumina sintered ceramics

Khaskhoussi, Amani; Calabrese, Luigi; Bouhamed, Hazem; Kamoun, Amel; Proverbio, E.; Bouaziz, Jamel

doi:10.1016/j.matdes.2017.10.010

Cited by 21 publications

(12 citation statements)

References 36 publications

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“…All specimens were coded by TxAxZx, X represents the amount (wt.%) of each added component. Microstructural and mechanical characterization and aging stability of ceramic mixtures have been reported in previous works [13][14][15].…”

Section: Ceramic Composites Manufacturingmentioning

confidence: 81%

“…TiO 2 has also showed excellent bioactivity, promoting the attachment of implants with living bone tissues in a short time [12]. Al 2 O 3 -ZrO 2 -TiO 2 ceramic composites for dental application have recently been developed [13][14][15]. The composition, physical properties, microstructure, and processing techniques of these new ceramic composites are different from those of the conventional ones used in dentistry, thus potentially influencing their inertness.…”

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confidence: 99%

“…The composition, physical properties, microstructure, and processing techniques of these new ceramic composites are different from those of the conventional ones used in dentistry, thus potentially influencing their inertness. Thus, biosafety cannot be deduced from the analysis of one ceramic composition to other formulations or conditions [16].In our previous works [13][14][15]17], we successfully elaborated and optimized ternary Al 2 O 3 -ZrO 2 -TiO 2 ceramic composites, through an easy and low-cost manufacturing process, with high mechanical performances (stiffness, strength, and toughness) and an exceptional aging resistance. Indeed, our fabricated ternary ceramics showed higher aging resistance than the commercial zirconia based dental ceramics without any significant degradation of mechanical performances over a simulated duration of 40 years of clinical use [18].Based on our promising results, an improvement in the knowledge of the biocompatibility of these ternary ceramic composites is required in order to consider them potentially effective for dental implantology applications.The aim of this work is to study how the surface behavior (wettability) can influence the cytotoxicity and the genotoxicity of the ternary mixtures of Al 2 O 3 -ZrO 2 -TiO 2 ceramic composites with the purpose of identifying the key factors in determining the optimal formulation for dental implantology.…”

mentioning

confidence: 99%

“…In our previous works [13][14][15]17], we successfully elaborated and optimized ternary Al 2 O 3 -ZrO 2 -TiO 2 ceramic composites, through an easy and low-cost manufacturing process, with high mechanical performances (stiffness, strength, and toughness) and an exceptional aging resistance. Indeed, our fabricated ternary ceramics showed higher aging resistance than the commercial zirconia based dental ceramics without any significant degradation of mechanical performances over a simulated duration of 40 years of clinical use [18].…”

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confidence: 99%

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Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites

et al. 2020

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Dental implant biomaterials are expected to be in contact with living tissues, therefore their toxicity and osseointegration ability must be carefully assessed. In the current study, the wettability, cytotoxicity, and genotoxicity of different alumina-zirconia-titania composites were evaluated. The surface wettability determines the biological event cascade in the bioceramic/human living tissues interface. The measured water contact angle indicated that the wettability strongly depends on the ceramic composition. Notwithstanding the contact angle variability, the ceramic surfaces are hydrophilic. The cytotoxicity of human gingival fibroblast cells with materials, evaluated by an (3-(4,5 methylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) test, revealed an absence of any cytotoxic effect. A relationship was found between the cell viability and the wettability. It was subsequently deduced that the cell viability increases when the wettability increases. This effect is more pronounced when the titania content is higher. Finally, a comet test was applied as complementary biocompatibility test to detect any changes in fibroblast cell DNA. The results showed that the DNA damage is intimately related to the TiO 2 content. Genotoxicity was mainly attributed to ceramic composites containing 10 wt.% TiO 2 . Our research revealed that the newly developed high performance alumina-zirconia-titania ceramic composites contain less than 10 wt.% TiO 2 , and display promising surface properties, making them suitable for dental implantology applications. of alumina is also its main deficiency. Indeed, the high rate of fractures in various alumina-based implants was reported on by clinical evaluations [6]. Zirconia (ZrO 2 ) ceramics were then introduced in implantology due to their resistance to fracture, their toughness (which is higher than the alumina), and their excellent biocompatibility [7]. However, zirconia bioceramics have a low resistance to ageing due to their transformation from the tetragonal phase (t) to the monoclinic phase (m) in the human body. This transformation is accompanied by an expansion of about 4% to 5% in volume. This volumetric expansion creates compressive stresses resulting in the drop of mechanical performances [8].Up to now, great efforts have been made to produce a new class of dental biomaterials with high mechanical performances. The combination of the high stiffness of alumina and the excellent toughness of zirconia could be an effective strategy [9]. Nevertheless, the previous works on alumina-zirconia ceramic composites revealed complex and high cost manufacturing processes such as hot-press sintering [10].Furthermore, several additives, such as TiO 2 , have been used in order to improve the sintering and enhance the ceramic performances of composites [11]. TiO 2 has also showed excellent bioactivity, promoting the attachment of implants with living bone tissues in a short time [12]. Al 2 O 3 -ZrO 2 -TiO 2 ceramic composites for dental application have recently been developed [13][14][15]...

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Section: Ceramic Composites Manufacturingmentioning

confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites

et al. 2020

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“…Recent reports envisage the use of Ce 4+ , Ti 4+ , Ta 5+ , SiO 2 , Dy 3+ , and Gd 3+ as stabilizers in ZTA systems . The combination of improved fracture toughness and better resistance to phase degradation is determined by CeO 2 inclusions in ZTA systems …”

Section: Introductionmentioning

confidence: 99%

Structural, optical tuning, and mechanical behavior of zirconia toughened alumina through europium substitutions

Ponnilavan

Kannan

2018

J Biomed Mater Res

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The structural and optical features of zirconia toughened alumina (ZTA) due to the assorted range of Eu 3+ substitutions are demonstrated. The characterization studies affirm the pivotal role of Eu 3+ on the improved structural stability of ZTA and associated tetragonal zirconia (t-ZrO 2 ) ! cubic zirconia (c-ZrO 2 ) transformation. Eu 3+ prefers accommodation at the lattice sites of ZrO 2 and their gradual accumulation induces t-! c-ZrO 2 transition. Beyond the substitution limit, Eu 3+ reacts with Al 2 O 3 to form EuAlO 3 . Optical studies validate typical Eu 3+ emissions, and further, the emission spectrum also predicts the symmetry of Eu 3+ coordination at the ZrO 2 lattice. Uniform distribution of ZrO 2 and Al 2 O 3 grains throughout the microstructures are evident from the morphological analysis. Further, the influence of Eu 3+ on the enhanced mechanical stability of ZTA is ensured from indentation technique.

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Optimization of physical and mechanical properties of PC/ABS/PMMA blends by mixture design approach

Ezzeddine,

Elfehri,

Marcos‐Fernández

et al. 2024

Polymer International

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This study aims to investigate the recycling of end‐of‐life computer plastics, focusing on polycarbonate (PC) and acrylonitrile–butadiene–styrene (ABS) copolymer, which constitute a significant portion of collected computers. Through differential scanning calorimetry and infrared spectroscopy analyses, the properties of raw PC, ABS and poly(methyl methacrylate) (PMMA) were evaluated. Various blends of PC and ABS were prepared, incorporating different percentages of recycled PMMA as a cost‐effective coupling agent. These blends were processed through melt compounding using a contra‐rotating twin‐screw extruder and subsequently shaped by injection molding. An experimental mixture design was applied to evaluate the mechanical and physical properties of the composite materials, including melt flow index, hardness, flexural strain at break and Charpy impact strength. The results of the desirability analysis indicated that the optimal blend for achieving a balance between mechanical and physical properties consists of a high PC content (approximately 80% or more), a low ABS content (less than 20%) and less than 5% recycled PMMA. © 2024 Society of Chemical Industry.

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Mixture design approach to optimize the performance of TiO2 modified zirconia/alumina sintered ceramics

Cited by 21 publications

References 36 publications

Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites

Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites

Structural, optical tuning, and mechanical behavior of zirconia toughened alumina through europium substitutions

Optimization of physical and mechanical properties of PC/ABS/PMMA blends by mixture design approach

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