Mixture of environmental pollutants in breast milk from a Spanish cohort of nursing mothers

Rovira, Joaquim; Martínez, María Ángeles; Mari, Montse; Cunha, Sara C.; Fernandes, José O.; Marmelo, Isa; Marques, António; Haug, Line Småstuen; Thomsen, Cathrine; Nadal, Martí; Domingo, José L.; Schuhmacher, Marta

doi:10.1016/j.envint.2022.107375

Cited by 48 publications

(22 citation statements)

References 72 publications

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“…In addition, DDE, a product of DDT degradation, was found in the milk of most participants. Although European countries also found a presence of DDT in human milk, like a Spanish cohort study with milk collection between 1 and 9 months postpartum, inequities could be observed, with low-income mothers presenting higher DDT and DDE concentrations in milk (Rovira et al 2022).…”

Section: Discussionmentioning

confidence: 93%

Association of pre-pregnancy maternal overweight/obesity and dietary intake during pregnancy with the levels of persistent organic pollutants in the human milk of Brazilian women

Ferreira

Freitas-Costa

Freire

et al. 2022

Preprint

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Persistent organic pollutants (POPs) are toxic chemical compounds that can bioaccumulate, adhere to lipid matrices, and affect human health. This study aimed to investigate the association between maternal pre-pregnancy overweight/obesity or dietary intake during pregnancy and POPs concentrations in the human milk of Brazilian women. A total of 77 women were followed from the third trimester of pregnancy until 119 days postpartum. Pregnancy dietary intake, which was estimated using a semi-quantitative food frequency questionnaire, and pre-pregnancy body mass index were collected at baseline. Human milk samples were collected between 2 and 119 days postpartum, and POPs concentrations were analysed using gas chromatography-triple quadrupole mass spectrometry. Multivariate logistic regression and linear regression models were used to investigate the association between pre-pregnancy overweight/obesity, dietary intake during pregnancy, and POPs concentrations in human milk. The analysis was adjusted for the maternal age and schooling, total cholesterol serum levels, and time postpartum and corrected for multiple comparisons using the Benjamini–Hochberg test. Significant associations were observed in the adjusted models between pre-pregnancy overweight/obesity and dichlorodiphenyldichloroethane (ppDDE), polychlorinated biphenyl (PCB)74, PCB138, PCB153, PCB170, PCB180, total PCBs, total 4PCBs, total 2 organochlorine pesticides (OCPs), and total POPs concentrations; and higher daily lipid intake during pregnancy increased human milk hexachlorobenzene (HCB). Collectively, this study showed that pre-pregnancy overweight/obesity and total lipid intake during pregnancy were associated with POPs concentrations in the milk of Brazilian women. To promote adequate nutritional status since preconception and surveillance and control of POP in the environment could be essential to ensure binomial mother-infant health.

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Section: Discussionmentioning

confidence: 93%

Association of pre-pregnancy maternal overweight/obesity and dietary intake during pregnancy with the levels of persistent organic pollutants in the human milk of Brazilian women

Ferreira

Freitas-Costa

Freire

et al. 2022

Preprint

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“…Although, no optimal levels of Cu in human milk were established yet in human milk.The median Se concentrations found in this study were 23.6 µg/L in the rst month and then decreased to 14.15 µg/L at 3 months and 10.41 µg/L at 6 months postpartum. Another study also found similar level of Se at 1-month which was 22(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) µg/L but higher level at 3 months postpartum, of 21 (16-25) µg/L (Motoyama et al, 2021). However, a previous study by Mandiá et al (2021) reported lower mean Se values of 8.87 µg/L in the mature milk compared to the current study which was 24.82 µg/L.…”

mentioning

confidence: 74%

Determination of zinc, copper, selenium, and manganese in human milk using acid digestion by ICP-MS and its application in biological trace element monitoring

Taufek

Sabere

Jamahari

et al. 2023

Preprint

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Human milk contains essential trace elements which support healthy development of infants. Previous studies have reported various analytical methods using different instruments to measure trace elements in human milk. This study aimed to determine the trace element concentration in human milk using a validated acid digestion method and its application in biomonitoring. Human milk samples were collected from three postpartum mothers and prepared using acid digestion method. All samples were analyzed using ICP-MS and all validation parameters were measured. Four trace elements which were zinc, copper, manganese and selenium were found to have good linearity (r² > 0.99), limit of detection in µg/L (0.06, 0.0001, 0.005, 0.00003, respectively) and limit of quantification in µg/L (0.18,0.0003, 0.02, 0.0001, respectively). The accuracy (83.4–112.7%), inter-day, and intra-day repeatability were within the acceptable limit. The method application on one case study showed the median levels of zinc, copper and selenium in human milk gradually decreased during the early six months, whereas manganese remained stable. Positive significant correlations were observed for most of the elements (r > 0.40, p < 0.001) except for copper-manganese. Acid digestion method is sensitive, accurate and precise to analyze and quantify zinc, copper, manganese and selenium concentrations in human milk simultaneously by ICP-MS. It can be applied in future studies to monitor trace elements concentration in human milk in future studies with larger sample size.

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“…In detail, for example, one study detected 31 organic contaminants and 14 toxic and essential elements in breast milk samples from a Spanish cohort of nursing mothers, stored in a biobank [ 122 ]. Some contaminants were found to be higher in breast milk samples from low-income mothers, such as dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE), and differences were also seen in primiparous mothers compared with multiparous [ 122 ]. Higher levels of bisphenol A (BPA) in low-income pregnant US women have been described and have been associated with adverse effects on offspring [ 123 ].…”

Section: Resultsmentioning

confidence: 99%

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

et al. 2023

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Metabolic syndrome (MetS) is defined by a cluster of several cardio-metabolic risk factors, specifically visceral obesity, hypertension, dyslipidemia, and impaired glucose metabolism, which together increase risks of developing future cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D). This article is a narrative review of the literature and a summary of the main observations, conclusions, and perspectives raised in the literature and the study projects of the Working Group of Childhood Obesity (WGChO) of the Italian Society of Paediatric Endocrinology and Diabetology (ISPED) on MetS in childhood obesity. Although there is an agreement on the distinctive features of MetS, no international diagnostic criteria in a pediatric population exist. Moreover, to date, the prevalence of MetS in childhood is not certain and thus the true value of diagnosis of MetS in youth as well as its clinical implications, is unclear. The aim of this narrative review is to summarize the pathogenesis and current role of MetS in children and adolescents with particular reference to applicability in clinical practice in childhood obesity.

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Mixture of environmental pollutants in breast milk from a Spanish cohort of nursing mothers

Cited by 48 publications

References 72 publications

Association of pre-pregnancy maternal overweight/obesity and dietary intake during pregnancy with the levels of persistent organic pollutants in the human milk of Brazilian women

Association of pre-pregnancy maternal overweight/obesity and dietary intake during pregnancy with the levels of persistent organic pollutants in the human milk of Brazilian women

Determination of zinc, copper, selenium, and manganese in human milk using acid digestion by ICP-MS and its application in biological trace element monitoring

Skeptical Look at the Clinical Implication of Metabolic Syndrome in Childhood Obesity

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