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Abstract

The action of PRP is characterized by the pronounced activation of the background activity (BA) of the brain spinal cord, and the degree of the activity depends on BA initial level. The typical peculiarity of Vipera raddei venom influence is the initial increase in frequency of BA with subsequent depression. A preliminary injection of PRP has a protective effect at subsequent influence of venom. In animals with hemisection the PRP increases the decreased activity of neurons on injury side. Taking into consideration the protective peculiarities of PRP in the relationship to snake venom and the possibility of the latter to stabilize and prolong the action of drugs (in the case of PRP) combined with them, it is supposed that the mentioned use of the combination in clinical practice will be perspective. The data obtained testify the PRP to be a neuroprotector against many toxic compounds formed in organism (glutamate, ceramid, beta-amyloid neurotoxisity, etc.). Investigations in this aspect are still in the process.

PRP‑1 significantly decreases the ALDHhigh cancer stem cell population and regulates the aberrant Wnt/β‑catenin pathway in human chondrosarcoma JJ012�cells

“…A subset of cultured human JJ012 chondrosarcoma cells were treated with incrementally increasing doses of 1, 5, 10 and 20 µg/ml PRP-1 and incubated at 37°C in a humidified atmosphere of 5% CO 2 for a period of 24 h prior to cytoplasmic and nuclear fractionation. PRP-1 was initially isolated from the brain hypothalamus (4).…”

“…Proline-rich polypeptide 1 (PRP-1), also known as galarmin, is produced by the neurosecretory cells of the brain (4). The cytostatic, antiproliferative, immunomodulatory, and tumor suppressor properties of PRP-1 suggest its potential as a therapeutic agent in human chondrosarcoma cells resistant to radiation and chemotherapy (4–9).…”

Proline-rich Polypeptide-1 Protects the Cells In Vitro from Genotoxic Effects of Mitomycin C

“…], promotes the oxygen burst in neutrophils and macrophages and increases the level of antibody production in B-lymphocytes [7]. PRP-1 is involved in the regulation of myelo-and lymphopoiesis [8][9][10][11][12]. It functions as a mediator in hypothalamus-neurohypophysis-bone marrow axis.…”

“…It functions as a mediator in hypothalamus-neurohypophysis-bone marrow axis. In general, PRP-1 is a unique regulator of various functions of the organism [4,[8][9][10]12] and seems to be a potential medicine.…”