MMP-2 expression associates with CA 125 and clinical course in endometrial carcinoma

Honkavuori, Maria; Talvensaari-Mattila, Anne; Soini, Ylermi; Turpeenniemi‐Hujanen, Taina; Santala, Markku

doi:10.1016/j.ygyno.2006.08.006

Cited by 34 publications

(34 citation statements)

References 15 publications

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“…In line with previous result [13, 15,17,18], we found in this study that the expression of steroid receptors, metallopro- In contrast to the current study, there is in the literature data that shows the association between MMP-2 and MMP-9 expression and the FIGO stage of endometrial cancer [19]. However, there is also data that, like our results, reveals no correlation between the examined MMPs and clinical and pathological parameters [6,7,15]. It is worth mentioning that, in our study, the expression of MMP-2 and MMP-9 was observed mainly in cases with advanced FIGO stage, and that MMP-9 immunopositivity was found in a greater area of tissue than in the case of cancers with less advanced FIGO stages.…”

Section: Discussionsupporting

confidence: 90%

“…In endometrial cancer, even in cases diagnosed at stages I and II of the FIGO classification, a cancer recurrence or metastatic spread can appear [6]. To assess the risk of recurrence in patients with endometrial cancer, many biological factors, such as tyrosine kinase receptors, steroid receptors, and proteins associated with me- www.fhc.viamedica.pl tastasis, have been analyzed [7].…”

Section: Introductionmentioning

confidence: 99%

“…MMPs play important roles in invasion and metastasis by regulating the signaling pathways that control cell growth and invasion [10]. Of all the metalloproteinases, the type-IV collagenase group of MMP-2 and MMP-9 has been linked to endometrial cancer progression and invasion [6]. Expression of different factors facilitates a subclone of a tumor cell growing to micrometastasis, allowing tumor cell outgrowth at a new, distant site [10].…”

Section: Introductionmentioning

confidence: 99%

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The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Gryboś

Bär

2014

Folia Histochem Cytobiol.

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Abstract:The role of the parallel expression of the KAI1 protein and metalloproteinases (MMP-2 and MMP-9) in respect to the status of steroid receptors in endometrial cancer is still incompletely understood. The aim of this study was to evaluate the expression of and correlation between KAI1 on one hand and MMP-2 and MMP-9 on the other hand in terms of the status of the estrogen (ER) and progesterone receptors (PR) in 100 patients with endometrial cancer. The expressions of KAI1, MMP-2, MMP-9, ER and PR were assessed immunohistochemically on paraffin-embedded tissues. No correlations were found between these biomarkers and the clinical and pathological parameters of the endometrial cancer. However, in KAI1-positive cases, the expression was limited to a small area of tumor tissue in FIGO stages III-IV. A tendency towards the high expression of MMP-9 and MMP-2 was observed in the advanced stages of endometrial cancer (FIGO IIIA-IV). Positive correlations between the presence of KAI1 and PR and between the presence of MMP-9 and PR were found in endometrial cancer. A positive correlation was also observed between KAI1 and MMP-2 expression, and a borderline one between KAI1 and MMP-9 expression in endometrial cancer. KAI1 -/MMP-2 + and KAI1 -/MMP-9 + phenotypes were more often observed in FIGO stage II. Our study showed that KAI1 protein, as well as steroid receptors, might modulate MMP-2 and MMP-9 expression in endometrial cancer. Our study revealed that the overlapping expression of the biomarkers investigated here suggests that cooperation between these molecules exists, even at the early stages of endometrial cancer growth, and may determine the speed of tumor cell dissemination and might characterize the biological behavior of endometrial cancer.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Gryboś

Bär

2014

Folia Histochem Cytobiol.

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“…For example, MMP2, MMP7, and MMP9 have been believed to be related with the progression and prognosis of endometrial carcinoma (17), colorectal cancer (18), gastric cancer (19,20), and breast cancer (21). MMP11 is an interesting member of the MMP family, and its overexpression has been shown in human cancers such as oral cancer (22,23), desmoid tumors (24), non -small cell lung cancer (25), and esophageal adenocarcinoma (26).…”

Section: Discussionmentioning

confidence: 99%

Identification of Matrix Metalloproteinase 11 as a Predictive Tumor Marker in Serum Based on Gene Expression Profiling

Yang

Deng

et al. 2008

Clinical Cancer Research

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Purpose: Prognostic markers discovery is a strategy for early diagnosis and individualization therapy for human cancer. In this study, we focus to integrate different methods to identify specific biomarker and elucidate its clinical significance. Experimental Design: A powerful tool named Digital Gene Expression Display online was applied to isolate differentially expressed genes correlated with gastric cancer. Matrix metalloproteinase 11 (MMP11) was selected and confirmed at both mRNA and protein level in 10 cell lines, 123 cases of tumor tissues, and 305 cases of gastric cancer serum specimen by semiquantitative PCR, immunohistochemistry staining, and ELISA techniques, respectively. Results: Our data showed that overexpression of MMP11 at mRNA and protein level was consistently detected in cell lines and primary tumors compared with matched normal tissues. Importantly, serum MMP11 levels were also significantly elevated in gastric cancer patients compared with those of the control subjects (P < 0.001), and the positive expression was well correlated with metastasis in gastric cancer patients (P = 0.009). Furthermore, we have shown that overexpression of MMP11was associated with the malignant proliferation of AGS cells. Conclusions: Combination of gene expression profiling and specific clinical resource is a promising approach to validate gene expression patterns associated with malignant phenotype. As a secreted protein, MMP11 may play an important role in carcinogenesis and has potential implication as a biomarker for the diagnosis and prognosis of human cancers including gastric cancer.

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“…The results presented in our study are in concordance with previously published reports. MMP2 expression in endometrial tumors has been analyzed in different patient populations, and several studies described its increased expression in EC cells, as well as a link between MMP2 immunostaining and tumor histological grade, depth of myometrial invasion, vascular or lymphatic invasion, and shorter overall survival (28)(29)(30)(31)(32). Despite the ambiguous role of TIMP2 in the regulation of MMP2 activity, its down-regulation in EC cells has been associated with MMP2 hyperactivation and malignant tumor behavior.…”

Section: Discussionmentioning

confidence: 99%

Post-transcriptional Regulation of MMP16 and TIMP2 Expression via miR-382, miR-410 and miR-200b in Endometrial Cancer

Rak

Mehlich

Garbicz

et al. 2017

CGP

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MMP-2 expression associates with CA 125 and clinical course in endometrial carcinoma

Cited by 34 publications

References 15 publications

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

The relationships between the immunoexpression of KAI1, MMP-2, MMP-9 and steroid receptors expression in endometrial cancer

Identification of Matrix Metalloproteinase 11 as a Predictive Tumor Marker in Serum Based on Gene Expression Profiling

Post-transcriptional Regulation of MMP16 and TIMP2 Expression via miR-382, miR-410 and miR-200b in Endometrial Cancer

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