Mn(III) mixed‐ligand complexes with <i>bis</i>‐pyrazolones and ciprofloxacin drug: synthesis, characterization and antibacterial activities

Modi, Chetan K.; Jani, Darshan H.

doi:10.1002/aoc.1782

Cited by 10 publications

(3 citation statements)

References 83 publications

(49 reference statements)

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“…Coordination compounds containing pyrazolone-based ligands are reported to be superior reagents in antimicrobial agents. In 2011, a research about Mn(III) mixed-ligand complexes with bis-pyrazolones and ciprofloxacin drug was published [40], the antimicrobial outcome showed that when added into the strains of microorganisms (E. coli, Serratia marcescens, S. aureus and B. subtilis), the mixed-ligand complexes which contain the moiety of bis-pyrazolones and ciprofloxacin exhibited stronger inhibitory effect compared with bis-pyrazolones, in which compounds 53 and 54 ( Fig. 5) were the potential active antimicrobial agents.…”

Section: Coordination Pyrazolone Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

149

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a b s t r a c tThe pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.

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Section: Coordination Pyrazolone Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

149

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“…The ν(N-H) and ν(C = O) modes of the lateral chain in the uncoordinated Schiff base appearing at 3216 and 1680 cm −1 , respectively (28). The reaction of the enolic ligand with M(II) ion is revealed by the presence of a new band in the spectra of 1275-1281 cm −1 due to the ν(C-O) (enolic) (29). In addition, the phenolic-OH vibration of the Schiff base ligand (3380 cm −1 ) disappeared in the entrapped complexes.…”

Section: Resultsmentioning

confidence: 99%

Zeolite-Y entrapped bivalent transition metal complexes as hybrid nanocatalysts: density functional theory investigation and catalytic aspects

Modi

Trivedi

Chudasama

et al. 2014

Green Chemistry Letters and Reviews

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“…Heavy metal complexes with existing, non-specific drugs are also considered. It is well recognized that coordination of metal ions with pharmaceutically active substances may improve their activities and profoundly moderate toxicities [ 23 , 24 ]. While numerous metal–NSAIDS complexes were synthesized and thoroughly analyzed [ 25 , 26 , 27 , 28 , 29 ], only a few species with flufenamic acid have been reported, namely cobalt [ 30 ] nickel [ 19 ], copper [ 31 , 32 , 33 , 34 , 35 , 36 ] and zinc [ 14 , 36 , 37 , 38 ] complexes.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Complexes with Flufenamic Acid for Pharmaceutical Applications—A Novel Three-Centered Coordination Polymer of Mn(II) Flufenamate

et al. 2020

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Five complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with non-steroidal anti-inflammatory drug, flufenamic acid were synthesized: (1) [Mn3(fluf)6EtOH)(H2O)]·3EtOH; (2) [Co(fluf)2(EtOH)(H2O)]·H2O; (3) [Ni(fluf)2(EtOH)(H2O)]·H2O; (4) [Cu(fluf)2·H2O]; (5) [Zn(fluf)2·H2O]. All complexes were characterized by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The crystal structure of 1 was determined by the single crystal X-ray diffraction technique. It crystallizes in the triclinic space group P with three independent Mn(II) cations, six coordinated flufenamato ligands augmented with water and ethanol molecules in the inner coordination sphere. In this crystal, manganese atoms are multiplied by symmetry and form infinite, polymeric chains which extend along the [001] dimension. The Hirshfeld Surface analysis revealed changes in interaction assemblies around all metal centers. The antioxidant and antimicrobial activities were established for all complexes and free ligand for comparison. All compounds exhibit good or moderate bioactivity against Gram-positive bacteria and yeasts.

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Mn(III) mixed‐ligand complexes with bis‐pyrazolones and ciprofloxacin drug: synthesis, characterization and antibacterial activities

Cited by 10 publications

References 83 publications

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zeolite-Y entrapped bivalent transition metal complexes as hybrid nanocatalysts: density functional theory investigation and catalytic aspects

Transition Metal Complexes with Flufenamic Acid for Pharmaceutical Applications—A Novel Three-Centered Coordination Polymer of Mn(II) Flufenamate

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