MnO 2 nanosheets as an artificial enzyme to mimic oxidase for rapid and sensitive detection of glutathione

Liu, Jing; Meng, Lingjie; Fei, Zhaofu; Dyson, Paul J.; Jing, Xunan; Xing, Lei

doi:10.1016/j.bios.2016.11.046

Cited by 347 publications

(127 citation statements)

References 55 publications

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“…The structure of MnO 2 was confirmed by the powder X‐ray diffraction (XRD) as depicted in Figure S1 (Supporting Information). The characteristic diffraction peaks at 2θ = 9.17°, 18.58°, 28.43°, 36.60°, and 64.44° of MnO 2 corresponded to (001), (002), (003), (100), and (110) planes, respectively, indicating a poorly crystalline structure . In addition, the X‐ray photoelectron spectroscopy (XPS) data showed the strong Mn 2p 1/2 and Mn 2p 3/2 peaks at around 653.9 eV and 642.0 eV (Figure B,C), respectively, corresponding to Mn 4+ oxidation state .…”

Section: Resultsmentioning

confidence: 97%

A GSH‐Gated DNA Nanodevice for Tumor‐Specific Signal Amplification of microRNA and MR Imaging–Guided Theranostics

Yan

Lin

et al. 2019

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Developing tumor‐responsive diagnosis and therapy strategies for tumor theranostics is still a challenge owing to their high accuracy and specificity. Herein, an AND logic gated–DNA nanodevice, based on the fluorescence nucleic acid probe and polymer‐modified MnO2 nanosheets, for glutathione (GSH)‐gated miRNA‐21 signal amplification and GSH‐activated magnetic resonance (MR) imaging–guided chemodynamic therapy (CDT) is reported. In the presence of overexpressed miRNA and GSH (tumor cells), the nanodevice can be in situ activated and release significantly amplified fluorescence signals and MR signals. Conversely, the fluorescence signal is quenched and MR signal remains at the background level with low miRNA and GSH (normal cells), efficiently reducing the false‐positive signals by more than 50%. Under the guide of miRNA profiling and MR imaging, the tumor‐responsive hydroxyl radical (·OH) can effectively kill tumor cells. Furthermore, the nanodevice shows catalase‐like activity and glucose oxidase–like activity with the performance of O2 production and glucose consumption. This is the first time to fabricate a tumor‐responsive theranostic DNA nanodevice with tumor‐specific signal amplification of microRNA and GSH‐activated MR imaging for CDT, potential hypoxia relief and starvation therapy, which provides a new insight for designing smart theranostic strategies.

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Section: Resultsmentioning

confidence: 97%

A GSH‐Gated DNA Nanodevice for Tumor‐Specific Signal Amplification of microRNA and MR Imaging–Guided Theranostics

Yan

Lin

et al. 2019

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“…S6 (supporting information). Moreover, it can be observed from [60] descended along with the increased concentration of GSH, indicating a conversion of oxTMB to TMB [12]. Figure 9b shows the quantitative detection of GSH in the range of 0.6-180 μM.…”

Section: Robustness Of Peroxidase Activity Of Nis/mmt/go Nanocompositesmentioning

confidence: 93%

“…In recent years, many efforts have been motivated for the detection of H 2 O 2 based on peroxidase mimics, including oxides [8], sulfide [9], metal nanoparticles [10], and carbon nanomaterials [11]. In addition, various GSH sensors based on peroxidase mimics have been reported, such as MnO 2 nanosheets [12], Co 3 O 4 nanotubes [13], and dipyrromethene (BODIPY) derivatives [14]. Among the peroxidase mimics, nanocomposites Electronic supplementary material The online version of this article (https://doi.org/10.1007/s42114-018-0045-2) contains supplementary material, which is available to authorized users.…”

Section: Introductionmentioning

confidence: 99%

Novel synthesis of NiS/MMT/GO nanocomposites with enhanced peroxidase-like activity for sensitive colorimetric detection of glutathione in solution

Chen

Zhu

Yang

et al. 2018

Adv Compos Hybrid Mater

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In the present study, a facile method was proposed to prepare nickel sulfide (NiS) nanoparticles well-dispersed on the surface of montmorillonite/graphene oxide (MMT/GO). The NiS/MMT/GO nanocomposites were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), fluorescence spectrophotometry, etc. Significantly, the novel NiS/MMT/GO nanocomposites exhibited high peroxidase-like activity toward the typical chromogenic substrate, 3,3′,5,5′-tetramethylbenzidine (TMB). However, glutathione (GSH) could inhibit the peroxidase-like activity of NiS/ MMT/GO along with a visible color variation. Based on the color change of the system of nanocomposites-H 2 O 2 -TMB, a novel colorimetric sensor was designed and conveniently used to quantitatively detect H 2 O 2 as well as GSH. The limit of detection (LOD) of H 2 O 2 and GSH is 9.73 and 0.5043 μM, respectively. The proposed H 2 O 2 sensor has potential application in the field of biosensing, food, and environment.

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“…MnO 2 nanosheets used as artificial enzymes (nano-oxidases) were obtained by exfoliation of bulk material prepared by precipitation of MnCl 2 ·4H 2 O and a mixture of tetramethylammonium hydroxide (TMA·OH) and H 2 O 2 in aqueous solution [8]. α -MnO 2 nanosheets were also formed by co-precipitation of MnCl 2 ·4H 2 O and MnC 2 O 4 ·2H 2 O in aqueous solution with addition of sodium hydroxide to control the pH of the solution [87].…”

Section: Synthesis Of Mno2 Nanomaterialsmentioning

confidence: 99%

“…Today MnO 2 is an important functional metal oxide, which is technologically attractive for applications in different fields such as catalysts [3,4,5], absorbent of toxic metals [6], ion-sieves, molecular-sieves [7], artificial oxidase [8], component of the dry cell (Leclanché cell) [9], inorganic pigment in ceramics, electrodes for electrochemical batteries (lithium, magnesium, sodium) [10,11,12,13], and electrodes for supercapacitors [14,15]. MnO 2 has also been widely used in Duracell (alkaline) based barriers, photocatalytic activities, and electrolysis.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured MnO2 as Electrode Materials for Energy Storage

2017

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Manganese dioxides, inorganic materials which have been used in industry for more than a century, now find great renewal of interest for storage and conversion of energy applications. In this review article, we report the properties of MnO2 nanomaterials with different morphologies. Techniques used for the synthesis, structural, physical properties, and electrochemical performances of periodic and aperiodic frameworks are discussed. The effect of the morphology of nanosized MnO2 particles on their fundamental features is evidenced. Applications as electrodes in lithium batteries and supercapacitors are examined.

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MnO 2 nanosheets as an artificial enzyme to mimic oxidase for rapid and sensitive detection of glutathione

Cited by 347 publications

References 55 publications

A GSH‐Gated DNA Nanodevice for Tumor‐Specific Signal Amplification of microRNA and MR Imaging–Guided Theranostics

A GSH‐Gated DNA Nanodevice for Tumor‐Specific Signal Amplification of microRNA and MR Imaging–Guided Theranostics

Novel synthesis of NiS/MMT/GO nanocomposites with enhanced peroxidase-like activity for sensitive colorimetric detection of glutathione in solution

Nanostructured MnO2 as Electrode Materials for Energy Storage

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