MnO<sub>2</sub>@Ce6-loaded mesenchymal stem cells as an “oxygen-laden guided-missile” for the enhanced photodynamic therapy on lung cancer

Cao, Wenwu; Liu, Bin; Xia, Fangfang; Duan, Meng; Hong, Yu-Ping; Niu, Jiaqi; Wang, Lirui; Liu, Yanlei; Li, Can; Cui, Daxiang

doi:10.1039/c9nr07947e

Cited by 58 publications

(42 citation statements)

References 47 publications

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“…The MSCs-MnO 2 -Ce6 besides being highly biocompatible and biodegradable had no significant systemic toxicity. Some other relevant examples from this category of anticancer activity are discussed in Table 3 [ 312 ].…”

Section: Bio-nanocarriers For Clinical Management Of Lung Cancermentioning

confidence: 99%

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Rawal

Patel

2021

Nano-Micro Lett.

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Lung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways. It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences, bearing overall mortality to incidence ratio of 0.87. The dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as bionanotechnology. This review article deliberates insights and apprehensions on the recent prologue of nanobioengineering and bionanotechnology as an approach for the clinical management of lung cancer. The role of nanobioengineered (bio-nano) tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis, diagnosis, therapeutics, and theranostics for lung cancer management has been discussed. Bioengineered, bioinspired, and biomimetic bio-nanotools of considerate translational value have been reviewed. Perspectives on existent oncostrategies, their critical comparison with bio-nanocarriers, and issues hampering their clinical bench side to bed transformation have also been summarized.

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Section: Bio-nanocarriers For Clinical Management Of Lung Cancermentioning

confidence: 99%

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Rawal

Patel

2021

Nano-Micro Lett.

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“…can be used to decompose H 2 O 2 . For example, Cao et al 44 loaded MnO 2 @Ce6 nanoparticles into mesenchymal stem cells (MSC) and transported them to the tumor site. The massive absorption of MSCs by tumor tissues increases the accumulation of the nanoplatforms (MnO 2 @Ce6‐MSCs) inside the tumor.…”

Section: Improve Ros Generation Levelmentioning

confidence: 99%

Enhancement of tumor lethality of ROS in photodynamic therapy

Liu

Chen

et al. 2020

Cancer Medicine

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In the process of photodynamic therapy (PDT) treatment of tumors, reactive oxygen species (ROS) plays a key role in destroying tumor tissues. However, traditional PDT often has limited ROS killing capacity due to hypoxia in the tumor microenvironment (TME) or obstruction by the ROS defense system, resulting in poor efficacy. Therefore, enhancing the killing effect of ROS on tumors is the core of enhancing the anti‐tumor effect of PDT. In recent years, many studies have developed a series of strategies to enhance the ability of ROS to kill tumors in view of the limitations of the TME on PDT. This article summarizes the commonly used or innovative strategies in recent years, including not only frequently used methods for hypoxia in the TME but also innovative strategies to inhibit the ROS defense system.

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“…In this in vitro study, low-dose photodynamic therapy: (i) induced the reorganization of MSC cytoskeleton, with decrease in cell motility; (ii) induced the inhibition of GSK-3 and the activation of Erk1/2 signaling in MSCs; (iii) significantly upregulated the secretion of VEGF-A, IL-8, PAI-1, MMP-9, and other proangiogenic factors by MSCs; (iv) dramatically inhibited the secretion of pro-tumorigenic macrophage infiltration marker CCL2 (MCP-1) by MSCs and decreased MSC viability and immunogenicity when cultured with lymphocytes. In another study, MSCs loaded with photosensitizer MnO2@Ce6 successfully shipped these nanoparticles into lung cancer tumor sites, enhancing the effects of photodynamic therapy in vivo ( Cao et al, 2020 ). In sarcomas, tumor-initiating cells are thought to derive from MSCs, modified MSC were successfully used to deliver TNF-related apoptosis-inducing ligand (TRAIL) to induce tumor apoptosis, open novel therapeutic opportunities ( Grisendi et al, 2015 ).…”

Section: Evidence Of Stromal Cells Mediating Anticancer Effectsmentioning

confidence: 99%

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

Kamdje

Etet

Tagne

et al. 2020

Front. Cell Dev. Biol.

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The role of mesenchymal stromal cells (MSCs) in the tumor microenvironment is well described. Available data support that MSCs display anticancer activities, and that their reprogramming by cancer cells in the tumor microenvironment induces their switch toward pro-tumorigenic activities. Here we discuss the recent evidence of pro-tumorigenic effects of stromal cells, in particular (i) MSC support to cancer cells through the metabolic reprogramming necessary to maintain their malignant behavior and stemness, and (ii) MSC role in cancer cell immunosenescence and in the establishment and maintenance of immunosuppression in the tumor microenvironment. We also discuss the mechanisms of tumor microenvironment mediated reprogramming of MSCs, including the effects of hypoxia, tumor stiffness, cancer-promoting cells, and tumor extracellular matrix. Finally, we summarize the emerging strategies for reprogramming tumor MSCs to reactivate anticancer functions of these stromal cells.

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MnO₂@Ce6-loaded mesenchymal stem cells as an “oxygen-laden guided-missile” for the enhanced photodynamic therapy on lung cancer

Abstract: The critical issue in nanoscale medicine delivery systems is the targeted efficiency to guarantee the maximum accumulation of nanodrugs in tumors to exert better therapeutic action.

Cited by 58 publications

References 47 publications

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Enhancement of tumor lethality of ROS in photodynamic therapy

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

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MnO2@Ce6-loaded mesenchymal stem cells as an “oxygen-laden guided-missile” for the enhanced photodynamic therapy on lung cancer

Abstract: The critical issue in nanoscale medicine delivery systems is the targeted efficiency to guarantee the maximum accumulation of nanodrugs in tumors to exert better therapeutic action.

Cited by 58 publications

References 47 publications

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Enhancement of tumor lethality of ROS in photodynamic therapy

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

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Product

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MnO₂@Ce6-loaded mesenchymal stem cells as an “oxygen-laden guided-missile” for the enhanced photodynamic therapy on lung cancer