MnO₂ Coated Mesoporous PdPt Nanoprobes for Scavenging Reactive Oxygen Species and Solving Acetaminophen‐Induced Liver Injury

Abstract

As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen‐induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase‐like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)‐scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs’ therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.

Reactive Oxygen Species Scavenging Nanozymes: Emerging Therapeutics for Acute Liver Injury Alleviation

“… 103 Lu et al reported a MnO 2 -coated mesoporous PdPt alloy nanozyme with enhanced ROS-scavenging ability for the amelioration of APAP-induced ALI. 104 With the rapid progress of nanotechnology, nanomedicines with self-propulsion capability have garnered increasing attention due to their active drug delivery and deeper penetration ability. 105 However, most currently available ROS-scavenging nanozymes cannot actively eliminate ROS because they passively diffuse rather than self-charged propulsion.…”

A Zn-doped Fe3O4 nanoparticle@N, S and P doped Elaeagnus angustifolia gum derived carbon hybrid electrocatalyst: synthesis, characterization and electrochemical sensing of acetaminophen

“…15 Besides rapid sensing of APAP, various techniques are developed for the treatment of APAP-caused accidents. 16–18…”