Mo polyoxometalate nanoparticles inhibit tumor growth and vascular endothelial growth factor induced angiogenesis

Abstract

Tumor growth depends on angiogenesis, which can furnish the oxygen and nutrients that proliferate tumor cells. Thus, blocking angiogenesis can be an effective strategy to inhibit tumor growth. In this work, three typical nanoparticles based on polyoxometalates (POMs) have been prepared; we investigated their capability as antitumor and anti-angiogenesis agents. We found that Mo POM nanoparticles, especially complex 3, inhibited the growth of human hepatocellular liver carcinoma cells (HepG2) through cellular reactive oxygen species levels’ elevation and mitochondrial membrane potential damage. Complex 3 also suppressed the proliferation, migration, and tube formation of endothelial cells in vitro and chicken chorioallantoic membrane development ex vivo. Furthermore, western blot analysis of cell signaling molecules indicated that Mo POMs blocked the vascular endothelial growth factor receptor 2-mediated ERK1/2 and AKT signaling pathways in endothelial cells. Using transmission electron microscopy, we demonstrated their cellular uptake and localization within the cytoplasm of HepG2 cells. These results indicate that, owing to the extraordinary physical and chemical properties, Mo POM nanoparticles can significantly inhibit tumor growth and angiogenesis, which makes them potential drug candidates in anticancer and anti-angiogenesis therapies.

Hybrid Nanocomposite of Imidazolium Based Chitosan and Anderson-type Manganese Polyoxomolybdate for Boosting Drug Delivery Against Breast Cancer

“…Our results showed that treatment of MDAMB-231 cells with IC50 dose of MnMo6@CSIm-A NCs leads to decreased cell migration by 1.4-fold (P < 0.05) compared to MnMo6 alone after 24h. In line with these data, the inhibitory effect of molybdenum nanoparticles on migration of normal cells has been reported (77), which is the only report on the study of molybdenum nanoparticles on cell migration. Therefore, the results of the present study, which is one of the pioneers in evaluating the migration inhibitory effect of POM NCs, can lead to the development of related studies in this field.…”

Multifunctional Biodegradable Prussian Blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic Therapy and Intrinsic Tumor Metastasis Inhibition

“…The previous studies demonstrated that although some nanomaterials had a small impact on cancer cell proliferation, they impair the migration and metastasis of tumors. ,− Hence, we also explored the effect of PBA on tumor metastasis in vivo and in vitro . After a 27-day observation experiment, the lungs of each mouse were harvested, and metastatic nodes were counted.…”

Synthesis and adsorption properties of [Cu(L)2(H2O)]H2[Cu(L)2(P2Mo5O23)]·4H2O/Fe3O4 nanocomposites

“…Polyoxometalates (POMs) are a well-known class of inorganic clusters consisting of a metal-oxygen framework, which have shown unique physicochemical properties and various applications owing to their highly electronegative and oxo-enriched surfaces, controllable shape and size, tunable acid-base, redox, magnetic, catalytic, and photochemical properties. [12][13][14][15][16][17] On the other hand, magnetic Fe 3 O 4 nanoparticles are most widely known for their exceptional physicochemical properties, low cost, non-toxic nature as well as environmentally benign for industrial scale synthesis of ne chemicals. 18 The interdisciplinary integration of POMs and Fe 3 O 4 nanoparticles has accelerated with fundamental curiosity and promising applications.…”