Exploration of the Moon is considered a high priority in the overall strategy of the European Space Agency (ESA), together with activities in Low Earth Orbit and missions to Mars. The Lunar South Polar region presents key opportunities for scientific discovery and advancement of exploration capabilities, but is also a uniquely challenging operational environment for robotic missions and for human explorers. ESA has placed accessing this environment and the surface material found there as a high priority. In this context ESA is discussing with international partners, in particular with ROSCOSMOS, how these ambitions might be realized in cooperation. To support this work ESA is engaged in a range of mission level activities with ROSCOSMOS on the Luna-27/Luna-Resurs Lander mission as well as Lunar Polar Sample Return (LPSR). In addition to this ESA is undertaking, with European institutes and industries, a set of specific development activities which seek to address the challenges of operating in the challenging environment of the Lunar South Pole.