Health care is an information business with expanding use of information and communication technologies (ICTs). Current ICT tools are immature, but a brighter future looms in many areas. We examine six areas of ICT in health care: electronic health records (EHRs), health information exchange (HIE), patient portals, telemedicine, social media, and mobile devices and wearable sensors and monitors. In each of these areas, we examine the current status and future promise, highlighting how each might reach its promise.Steps to better EHRs include a universal programming interface, universal patient identifiers, improved documentation, and improved data analysis. HIEs will require federal subsidies for sustainability and support from EHR vendors, targeting seamless sharing of EHR data. Patient portals must bring patients into the EHR with better design and training, greater provider engagement, and leveraging HIEs. Telemedicine needs sustainable payment models, clear rules of engagement, and quality measures and monitoring. Social media needs consensus on rules of engagement for providers, better data mining tools, and approaches to counter disinformation. Mobile and wearable devices will benefit from a universal programming interface, improved infrastructure, more rigorous research, and integration with EHRs and HIEs.ICT tools are are evolving quickly in health care and require a rational and well-funded national agenda for development, use, and assessment.-3-