Mobilisation of Cadmium by meso- and racemic-2,3-Dimercaptosuccinic Acid (DMSA) in Rats

Blanuša, Maja; Kostial, Krista; Restek-Samaržija, Nada; Piasek, Martina; Jones, Mark M.; Singh, Pramod K.

doi:10.1034/j.1600-0773.2000.d01-70.x

Cited by 8 publications

(3 citation statements)

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“…In animal experiments, meso-DMSA was an efficient chelator for gold [153][154][155][156] and nickel [104,105]. Controversial results were obtained for cadmium [73,75,157,158], thallium [136,159], and platinum, either for tissue platinum reduction, or for platinum nephrotoxicity [160][161][162][163]. Graziano and coworkers [163], for example, found that although meso-DMSA treatment reduced renal platinum concentration in rats by 50%, it failed to prevent renal toxicity.…”

Section: Meso-23-dimercaptosuccinic Acid (Succimer Meso-dmsa)mentioning

confidence: 97%

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

Blanuša¹,

Varnai²,

Piasek³

et al. 2005

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The effects of chelating drugs used clinically as antidotes to metal toxicity are reviewed. Human exposure to a number of metals such as lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel and platinum may lead to toxic effects, which are different for each metal. Similarly the pharmacokinetic data, clinical use and adverse effects of most of the chelating drugs used in human metal poisoning are also different for each chelating drug. The chelating drugs with worldwide application are dimercaprol (BAL), succimer (meso-DMSA), unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa(2)EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa(3)DTPA, ZnNa(3)DTPA), deferoxamine (DFO), deferiprone (L1), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects. These include three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), the derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA) and the carbodithioates. Many factors have been shown to affect the efficacy of the chelation treatment in metal poisoning. Within this context it has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age. These findings may have a bearing in the design of new therapeutic chelation protocols for metal toxicity.

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Section: Meso-23-dimercaptosuccinic Acid (Succimer Meso-dmsa)mentioning

confidence: 97%

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

Blanuša¹,

Varnai²,

Piasek³

et al. 2005

CMC

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150

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“…15 However, in animals N-acetylcysteine (H 2 NAC), DMSA and zinc chelates of alkyl ester derivatives of DMSA have been successfully used in excreting cadmium. [16][17][18] N-acetylcysteine is a potent antioxidant, a scavenger for free radicals produced in cells, and a precursor of L-cysteine and glutathione. 19 Also, it has been widely used for treatment of cancer, HIV infections, cardiovascular diseases and metal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Cadmium(ii) N-acetylcysteine complex formation in aqueous solution

et al. 2011

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The complex formation between Cd(II) ions and N-acetylcysteine (H(2)NAC) in aqueous solution was investigated using Cd K- and L(3)-edge X-ray absorption and (113)Cd NMR spectroscopic techniques. Two series of 0.1 M Cd(II) solutions with the total N-acetylcysteine concentration c(H2NAC) varied between 0.2-2 M were studied at pH 7.5 and 11.0, respectively. At pH = 11 a novel mononuclear [Cd(NAC)(4)](6-) complex with the average Cd-S distance 2.53(2) Å and the chemical shift δ((113)Cd) = 677 ppm was found to dominate at a concentration of the free deprotonated ligand [NAC(2-)] > 0.1 M, consistent with our previous reports on cadmium tetrathiolate complex formation with cysteine and glutathione. At pH 7.5 much higher ligand excess ([HNAC(-)] > 0.6 M) is required to make this tetrathiolate complex the major species. The (113)Cd NMR spectrum of a solution containing c(Cd(II)) = 0.5 M and c(H2NAC) = 1.0 M measured at 288 K showed three broad signals at 421, 583 and 642 ppm, which can be attributed to CdS(3)O(3), CdS(3)O and CdS(4) coordination sites, respectively, in oligomeric Cd(II)-NAC species with single thiolate bridges between the cadmium ions.

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“…DMPS seemed to increase cadmium burden [74,80]. Succimer (DMSA) improved survival [80], modestly decreased cadmium retention [75,86], and provided dose-dependent survival benefit, although with increased renal burden [76]. Along with diethylenetriaminepentaacetate (DTPA), which yielded dose-dependent increased survival [76], decreased cadmium retention [75], and decreased residual cadmium [78], DMSA is probably the chelator that has shown the most benefit in animal models.…”

Section: Cadmium Chelators and Chelation Considerationsmentioning

confidence: 99%