Mobilization of Progenitor Cells into the Blood by Immobilized Granulocytic Colony-Stimulating Factor

Дыгай, А. М.; Верещагин, Е. И.; Zyuz’kov, G. N.; Zhdanov, V. V.; Мадонов, П. Г.; Симанина, Е. В.; Ставрова, Л. А.; Удут, Е. В.; Khrichkova, T. Yu.; Мирошниченко, Л. А.; Minakova, M. Yu.; Ермакова, Н. Н.; Firsova, T. V.

doi:10.1007/s10517-009-0550-y

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Our fi ndings and published data on specifi c activity of immobilized HD [6,9] and, obviously, its low toxicity [7] suggest that the development of drugs for regenerative medicine on the basis of HD [8,9] and approaches for improving the effi ciency and safety of therapy of various diseases with recombinant and other bioengineered protein drugs as analogs of endogenous regulators of physiological functions are promising trends.…”

Section: Resultsmentioning

confidence: 92%

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Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors

Дыгай¹,

Zyuz’kov²,

Zhdanov³

et al. 2011

Bull Exp Biol Med

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In vitro experiments demonstrated increased colony-forming capacity of erythroid, granulomonocytic, and mesenchymal progenitors of the bone marrow and parenchymal progenitor elements of the liver after treatment with immobilized hyaluronidase. Increased sensitivity of these progenitor cells to erythropoietin, granulocyte colony-stimulating factor, fibroblast growth factor, and stem cell factor, respectively, was demonstrated. Immobilized hyaluronidase enhanced the formation of tissue-specific hepatic CFU against the background of reduced yield of stromal precursors in liver tissue culture containing insulin.

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Section: Resultsmentioning

confidence: 92%

“…The maximum changes were observed in the earliest progenitor cells from BM, primarily fibroblast CFU containing not only stromal precursors, but also multipotent SC [7,12] and in hepatic progenitor cells.…”

Section: Resultsmentioning

confidence: 99%

Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors

Дыгай¹,

Zyuz’kov²,

Zhdanov³

et al. 2011

Bull Exp Biol Med

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“… Brasel et al [ 22 ]; Robinson et al [ 33 ] PEG-MGDF Pegylated megakaryocyte growth and development factor Multi-day PEG-MGDF alone can induce mobilization; PEG-MGDF synergizes with G-CSF to enhance mobilization. Torii et al [ 27 ], Honda et al [ 36 ] SD/01 a , IM G-CSF a , and PEGLip-G-CSF a Modified G-CSF Modified G-CSF exhibited superior mobilization potential compared with standard G-CSF De Haan et al [ 30 ], Dygai et al [ 62 ], Yatuv et al [ 65 ] GROβ and tGROβ b GROβ: CXCL2, a chemokine; tGROβ: truncated form of GROβ (also known as SB-251353, GROβ T , GROβ △4 ) Single-dose GROβ or tGROβ alone induced rapid mobilization; tGRO-β synergistically enhanced the mobilization effects of G-CSF, AMD3100, and VLA-4 antagonists. King et al [ 37 ], Pelus et al [ 47 ], Fukuda et al et al [ 54 ], Hoggatt et al [ 77 ], Karpova et al [ 107 ] rhPlGF-1 Recombinant human placental growth factor-1 rhPlGF-1 alone had no mobilizing activity; rhPlGF-1 synergized with G-CSF in mobilization.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the efficacy of hematopoietic stem cell mobilization regimens: a systematic review and network meta-analysis of preclinical studies

Luo

Wang

et al. 2021

Stem Cell Res Ther

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Background Mobilization failure may occur when the conventional hematopoietic stem cells (HSCs) mobilization agent granulocyte colony-stimulating factor (G-CSF) is used alone, new regimens were developed to improve mobilization efficacy. Multiple studies have been performed to investigate the efficacy of these regimens via animal models, but the results are inconsistent. We aim to compare the efficacy of different HSC mobilization regimens and identify new promising regimens with a network meta-analysis of preclinical studies. Methods We searched Medline and Embase databases for the eligible animal studies that compared the efficacy of different HSC mobilization regimens. Primary outcome is the number of total colony-forming cells (CFCs) in per milliliter of peripheral blood (/ml PB), and the secondary outcome is the number of Lin− Sca1+ Kit+ (LSK) cells/ml PB. Bayesian network meta-analyses were performed following the guidelines of the National Institute for Health and Care Excellence Decision Support Unit (NICE DSU) with WinBUGS version 1.4.3. G-CSF-based regimens were classified into the SD (standard dose, 200–250 μg/kg/day) group and the LD (low dose, 100–150 μg/kg/day) group based on doses, and were classified into the short-term (2–3 days) group and the long-term (4–5 days) group based on administration duration. Long-term SD G-CSF was chosen as the reference treatment. Results are presented as the mean differences (MD) with the associated 95% credibility interval (95% CrI) for each regimen. Results We included 95 eligible studies and reviewed the efficacy of 94 mobilization agents. Then 21 studies using the poor mobilizer mice model (C57BL/6 mice) to investigate the efficacy of different mobilization regimens were included for network meta-analysis. Network meta-analyses indicated that compared with long-term SD G-CSF alone, 14 regimens including long-term SD G-CSF + Me6, long-term SD G-CSF + AMD3100 + EP80031, long-term SD G-CSF + AMD3100 + FG-4497, long-term SD G-CSF + ML141, long-term SD G-CSF + desipramine, AMD3100 + meloxicam, long-term SD G-CSF + reboxetine, AMD3100 + VPC01091, long-term SD G-CSF + FG-4497, Me6, long-term SD G-CSF + EP80031, POL5551, long-term SD G-CSF + AMD3100, AMD1300 + EP80031 and long-term LD G-CSF + meloxicam significantly increased the collections of total CFCs. G-CSF + Me6 ranked first among these regimens in consideration of the number of harvested CFCs/ml PB (MD 2168.0, 95% CrI 2062.0−2272.0). In addition, 7 regimens including long-term SD G-CSF + AMD3100, AMD3100 + EP80031, long-term SD G-CSF + EP80031, short-term SD G-CSF + AMD3100 + IL-33, long-term SD G-CSF + ML141, short-term LD G-CSF + ARL67156, and long-term LD G-CSF + meloxicam significantly increased the collections of LSK cells compared with G-CSF alone. Long-term SD G-CSF + AMD3100 ranked first among these regimens in consideration of the number of harvested LSK cells/ml PB (MD 2577.0, 95% CrI 2422.0–2733.0). Conclusions Considering the number of CFC and LSK cells in PB as outcomes, G-CSF plus AMD3100, Me6, EP80031, ML141, FG-4497, IL-33, ARL67156, meloxicam, desipramine, and reboxetine are all promising mobilizing regimens for future investigation.

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Effects of Growth Factors on Mobilization of Mesenchymal Stem Cells

et al. 2017

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We studied mobilization of bone marrow stem cells the under conditions of boost-therapy with granulocytic CSF and erythropoietin. Immunophenotyping of the peripheral blood was carried out in patients after transplantation of tissue-engineered trachea during the perioperative period. We observed an increase in hemopoietic stem cell pool and appearance of multipotent mesenchymal stromal cells in systemic circulation, their maximum concentration being recorded on days 10-14 after surgery. These data indicated a positive effect of growth factors on mobilization of stem cells.

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Mobilization of Progenitor Cells into the Blood by Immobilized Granulocytic Colony-Stimulating Factor

Cited by 4 publications

References 9 publications

Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors

Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors

Comparison of the efficacy of hematopoietic stem cell mobilization regimens: a systematic review and network meta-analysis of preclinical studies

Effects of Growth Factors on Mobilization of Mesenchymal Stem Cells

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