2014
DOI: 10.1016/j.exphem.2014.03.009
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Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse

Abstract: ABSTRACTinflammation on bone, hematopoietic and erythropoietic maintenance and agents that affect these macrophages, such as G-CSF, are likely to affect these three processes concomitantly.

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Cited by 82 publications
(116 citation statements)
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“…1 and Ly6G 1 macrophages were identified as supporting BM erythropoiesis, 14,15 but other studies have concluded that CD169…”
Section: Introductionmentioning
confidence: 99%
“…1 and Ly6G 1 macrophages were identified as supporting BM erythropoiesis, 14,15 but other studies have concluded that CD169…”
Section: Introductionmentioning
confidence: 99%
“…We found that G-CSF and cyclophosphamide depletes F4/80 + osteomacs on endosteal surfaces associated with down-regulated expression of the Scf, Cxcl12 and Vcam1 genes [28]. G-CSF also depletes other macrophage subsets in the BM such as erythroblastic island macrophages leading to medullar anemia [33]. In two models of targeted macrophage depletion, such as injection of clodronate-loaded liposomes or macrophage-Fas-inducedapoptosis (Mafia) transgenic mice, macrophage depletions also leads to dramatic reduction of Cxcl12, Scf, Vcam1, and Angpt1 expression in the BM, loss of osteomacs and osteoblasts mobilization of HSPCs into the blood [28].…”
Section: Macrophagesmentioning
confidence: 79%
“…In two models of targeted macrophage depletion, such as injection of clodronate-loaded liposomes or macrophage-Fas-inducedapoptosis (Mafia) transgenic mice, macrophage depletions also leads to dramatic reduction of Cxcl12, Scf, Vcam1, and Angpt1 expression in the BM, loss of osteomacs and osteoblasts mobilization of HSPCs into the blood [28]. This effect of G-CSF may be autonomous to macrophages as macrophages also express Csf3r [33].…”
Section: Macrophagesmentioning
confidence: 99%
“…Jacobsen et al 18 recently investigated the effect of targeted depletion of bone marrow macrophages on medullary and extramedullary erythropoiesis. Treatment with pharmacologic doses of granulocyte colony-stimulating factor (G-CSF) specifically eliminates resident macrophages in the bone marrow.…”
Section: Birth: the Role Of Macrophages During Erythropoiesismentioning
confidence: 99%