Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study

Dackis, Charles A.; Lynch, Kevin G.; Yu, Elmer; Samaha, Frederick F.; Kampman, Kyle M.; Cornish, James; Rowan, Amy B.; Poole, Sabrina; White, Lenae; O’Brien, Charles P.

doi:10.1016/s0376-8716(02)00335-6

Cited by 165 publications

(142 citation statements)

References 73 publications

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“…We hypothesized that cocaine self-administration and subjective effects would be decreased as a function of modafinil maintenance condition. Although we assumed the cocaine-modafinil combination would be well tolerated, no prediction was made regarding the impact of modafinil maintenance on cocaine-induced cardiovascular effects because inconsistent results had been previously reported, that is, Dackis et al (2003) reported modafinil produced no significant effects, whereas Malcolm et al (2006) reported the drug decreased some cocaineevoked cardiovascular effects.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, findings from two laboratory studies of human cocaine abusers also support the utility of modafinil as a treatment medication for cocaine abuse (Dackis et al, 2003;Malcolm et al, 2006). The first report was a withinsubjects laboratory investigation, during which seven cocaine-dependent individuals were maintained on modafinil (placebo, 200, and 400 mg/day) for 4 days before receiving open-label cocaine (30 mg) i.v.…”

Section: Introductionmentioning

confidence: 99%

“…The first report was a withinsubjects laboratory investigation, during which seven cocaine-dependent individuals were maintained on modafinil (placebo, 200, and 400 mg/day) for 4 days before receiving open-label cocaine (30 mg) i.v. (Dackis et al, 2003). Physiological and subjective measures were assessed repeatedly after cocaine administration.…”

Section: Introductionmentioning

confidence: 99%

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Smoked Cocaine Self-Administration is Decreased by Modafinil

Hart

Haney

Vosburg

et al. 2007

Neuropsychopharmacol

160

159

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Modafinil has been reported to reduce cocaine use in a clinical sample of infrequent users (2 days/week), but the effects of modafinil on cocaine self-administration in the laboratory have not been studied. The present study investigated the effects of modafinil maintenance on cocaine self-administration by frequent users (4 days/week) under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of modafinil maintenance (0, 200, and 400 mg/day) on response to smoked cocaine (0, 12, 25, and 50 mg) were examined in nontreatment-seeking cocaine-dependent individuals (n ¼ 8). Cocaine significantly increased selfadministration, subjective-effect ratings, and cardiovascular measures; modafinil at both doses (200 and 400 mg/day) markedly attenuated these effects. These findings agree with data from previous human laboratory and clinical investigations of modafinil as a potential cocaine abuse treatment medication. Thus, our data support the potential of modafinil as a pharmacotherapy for cocaine dependence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Smoked Cocaine Self-Administration is Decreased by Modafinil

Hart

Haney

Vosburg

et al. 2007

Neuropsychopharmacol

160

159

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“…Une autre molécule semble très prometteuse : le modafinil. Agoniste glutamatergique, elle a montré son efficacité dans deux études randomisées [10,11], en association à une thérapie comportementale et cognitive, en aidant les patients à rester plus longtemps abstinents que le placebo et en réduisant les effets positifs induits par la prise de cocaïne.…”

Section: Thérapeutiqueunclassified

Le point sur l’addiction à la cocaïne et au crack

Charles-Nicolas

Lacoste

Ballon

2009

Annales Médico-psychologiques, revue psychiatrique

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“…Modafinil is a nonamphetamine psychostimulant that was initially approved for the treatment of narcolepsy but was subsequently shown to have success in clinical trials treating cocaine dependence (Anderson et al, 2009;Dackis, Kampman, Lynch, Pettinati, & O'Brien, 2005;Dackis et al, 2003). The pharmacological mechanism(s) of modafinil's action has yet to be clearly determined (see Minzenberg & Carter, 2007, for a review), with effects on multiple neurotransmitter systems including catecholamine, serotonin, glutamate, GABA, orexin, and histamine systems.…”

mentioning

confidence: 99%

The effects of modafinil treatment on neuropsychological and attentional bias performance during 7-day inpatient withdrawal from methamphetamine dependence.

Hester¹,

Lee²,

Pennay³

et al. 2010

Experimental and Clinical Psychopharmacology

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The cognitive benefits of modafinil to patients undergoing 7-day inpatient withdrawal from methamphetamine (MA) dependence were examined as part of a double-blind, randomized, placebo-controlled pilot trial. Recent evidence has identified modafinil-related improvements in treatment outcomes for MA-dependent patients; however, the benefits to cognition function, which is critical to treatment success but known to be impaired, has yet to be examined. The first 20 participants recruited to the study were administered either 200 mg of modafinil (once daily) or placebo, and a neuropsychological test battery (including an MA version of the emotional Stroop task) at admission (n ϭ 17) and discharge (n ϭ 14). Follow-up interviews were conducted at 1-month postdischarge (n ϭ 13). After participant withdrawals (3 in each group), treatment was associated with a significant improvement in immediate verbal memory recall and nonsignificant trend toward improvement on executive function and delayed memory tasks. No benefit was seen for measures of verbal learning, visual memory, processing speed, or verbal fluency. All participants showed a significant attentional bias for MA-related stimuli on the emotional Stroop task. The magnitude of bias predicted both retention in treatment and relapse potential at follow-up but was not significantly ameliorated by modafinil treatment. While nonsignificant, the effect sizes of modafinil-related improvements in executive function and memory were consistent with those found in more robustly powered studies of cognitive benefits in attention-deficit/hyperactivity disorder and schizophrenia, supporting the need for further research.

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Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study

Cited by 165 publications

References 73 publications

Smoked Cocaine Self-Administration is Decreased by Modafinil

Smoked Cocaine Self-Administration is Decreased by Modafinil

Le point sur l’addiction à la cocaïne et au crack

The effects of modafinil treatment on neuropsychological and attentional bias performance during 7-day inpatient withdrawal from methamphetamine dependence.

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