A systematic study of 12 ferric and ferrous Kbeta X-ray emission spectra (XES) is presented. The factors contributing to the Kbeta main line and the valence to core region of the spectra are experimentally assessed and quantitatively evaluated. While the Kbeta main line spectra are dominated by spin state contributions, the valence to core region is shown to have greater sensitivity to changes in the chemical environment. A density functional theory (DFT) based approach is used to calculate the experimental valence spectra and to evaluate the contributions to experimental intensities and energies. The spectra are found to be dominated by iron np to 1s electric dipole allowed transitions, with pronounced sensitivity to spin state, ligand identity, ligand ionization state, hybridization state, and metal-ligand bond lengths. These findings serve as an important calibration for future applications to iron active sites in biological and chemical catalysis. Potential applications to Compound II heme derivatives are highlighted.

'Ecstasy' (3,4-methylenedioxymethamphetamine or MDMA) is a recreational drug that is gaining popularity world wide. There is a paucity of research regarding the ways in which Ecstasy is used and the nature of its effects. A 'snowball' peer network technique was used to recruit 100 users who completed anonymous questionnaires. The research revealed that Ecstasy is primarily used by infrequent recreational drug users for 'fun' at dance parties and social gatherings. The primary reported effects of Ecstasy were a 'positive mood state' and feelings of intimacy and closeness to others. The secondary effects of Ecstasy were the stimulant effects of energy and activation, and the psychedelic effects of insight and perceptual and sensual enhancement. Ecstasy was reported to share the properties of both amphetamines and hallucinogens in the nature of its side effects and residual effects which were no more severe than those of the latter two classes of drug. It appeared Ecstasy was not conductive to regular and frequent use, because tolerance was reported to develop to the positive effects of Ecstasy, while negative effects increased with use. Although few problems associated with the recreational use of Ecstasy have surfaced to date, animal research has shown it to be neurotoxic to serotonergic nerve terminals. Caution must be observed until further research can determine the level of hazard in humans.

Experiential training and personal therapy have rich traditions in various therapies as strategies to enhance self-awareness and therapist skills. However, personal experiential work has not traditionally been part of cognitive therapy (CT) training. The purpose of the present study is to map the impact of personal experiential work on CT skills in a group of CT practitioners. Fourteen cognitive therapists undertook training courses utilizing a structured approach to self-practice of CT techniques, known as self-practice/self-reflection (SP/ SR). Six therapists from one training group engaged in ''co-therapy'' sessions with a partner, while eight therapists from another training group practised CT techniques on their own. Both groups engaged in regular written reflections about their experience. Follow-up 1-5 months after the courses identified six areas of self-reported skill enhancement: Refinement of specific CT skills; Enriched communication of the conceptual framework of CT; Increased attention to the therapeutic relationship; Empathic attunement; Therapist self-reflection; and Therapeutic flexibility. The results suggested that SP/SR enhances the ''professional artistry'' of therapists, a finding consistent with literature suggesting that reflection is a key process in the development of therapist expertise. It is concluded that SP/SR represents a promising training strategy for cognitive therapists.

Conservation agriculture (CA)-the simultaneous application of minimum soil disturbance, crop residue retention, and crop diversification-is a key approach to address declining soil fertility and the adverse effects of climate change in southern Africa. Applying the three defining principles of CA alone, however, is often not enough, and complementary practices and enablers are required to make CA systems more functional for smallholder farmers in the short and longer term. Here, we review 11 complementary practices and enablers grouped under six topical areas to highlight their critical need for functional CA systems, namely: (1) appropriate nutrient management to increase productivity and biomass; (2) improved stress-tolerant varieties to overcome biotic and abiotic stresses; (3) judicious use of crop chemicals to surmount pest, diseases, and weed pressure; (4) enhanced groundcover with alternative organic resources or diversification with green manures and agroforestry; (5) increased efficiency of planting and mechanization to reduce labor, facilitate timely planting, and to provide farm power for seeding; and (6) an enabling political environment and more harmonized and innovative extension approaches to streamline and foster CA promotional efforts. We found that (1) all 11 complementary practices and enablers substantially enhance the functioning of CA systems and some (e.g., appropriate nutrient management) are critically needed to close yield gaps; (2) practices and enablers must be tailored to the local farmer contexts; and (3) CA systems should either be implemented in a sequential approach, or initially at a small scale and grow from there, in order to increase feasibility for smallholder farmers. This review provides a comprehensive overview of practices and enablers that are required to improve the productivity, profitability, and feasibility of CA systems. Addressing these in southern Africa is expected to stimulate the adoption of CA by smallholders, with positive outcomes for soil health and resilience to climate change.

Among men, depression is often unrecognised and untreated. Men employed in male-dominated industries and occupations may be particularly vulnerable. However, efforts to develop tailored workplace interventions are hampered by lack of prevalence data. A systematic review of studies reporting prevalence rates for depression in male dominated workforce groups was undertaken. Studies were included if they were published between 1990 - June 2012 in English, examined adult workers in male-dominated industries or occupations (> 70% male workforce), and used clinically relevant indicators of depression. Twenty studies met these criteria. Prevalence of depression ranged from 0.0% to 28.0%. Five studies reported significantly lower prevalence rates for mental disorders among male-dominated workforce groups than comparison populations, while six reported significantly higher rates. Eight studies additionally found significantly higher levels of depression in male-dominated groups than comparable national data. Overall, the majority of studies found higher levels of depression among workers in male-dominated workforce groups. There is a need to address the mental health of workers in male-dominated groups. The workplace provides an important but often overlooked setting to develop tailored strategies for vulnerable groups.