Modafinil as a Replacement for Dextroamphetamine for Sustaining Alertness in Military Helicopter Pilots

Estrada, Arthur; Kelley, Amanda M; Webb, Catherine M.; Athy, Jeremy R; Crowley, John S.

doi:10.3357/asem.3129.2012

Cited by 76 publications

(36 citation statements)

References 20 publications

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“…In contrast, in a more recent study, Dackis et al (2012) showed that modafinil failed to decrease the positive urine samples for cocaine in drug addicts. Another concern regarding the clinical relevance of our study is the increasing use of modafinil for non-medical purposes, such as to increase cognitive ability (Cakic, 2009), to sustain alertness in military pilots (Estrada et al, 2012) and even to improve performance in athletes (Strano Rossi and Botrè, 2011). Of note, recent studies have demonstrated that modafinil produces a number of serious side effects, such as psychotic symptoms (Wu et al, 2008) and severe cutaneous (Stevens-Johnson Syndrome) and cardiovascular adverse reactions (Carstairs et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

et al. 2016

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There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on arousal and cognition. The rapid-onset type of behavioral sensitization (i.e., a type of sensitization that develops within a few hours from the drug priming administration) has been emerged as a valuable tool to study binge-like patterns of drug abuse and the neuroplastic changes that occur quickly after drug administration that ultimately lead to drug abuse. Our aim was to investigate the possible development of rapid-onset behavioral sensitization to modafinil and bidirectional rapid-onset cross-sensitization with cocaine in male Swiss mice. A priming injection of a high dose of modafinil (64 mg/kg) induced rapid-onset behavioral sensitization to challenge injections of modafinil at the doses of 16, 32, and 64 mg/kg, administered 4 h later. Furthermore, rapid-onset cross-sensitization was developed between modafinil and cocaine (64 mg/kg modafinil and 20 mg/kg cocaine), in a bidirectional way. These results were not due to residual levels of modafinil as the behavioral effects of the priming injection of modafinil were no longer present and modafinil plasma concentration was reduced at 4 h post-administration. Taken together, the present findings provide preclinical evidence that modafinil can be reinforcing per se and can enhance the reinforcing effects of stimulants like cocaine within hours after administration.

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Section: Discussionmentioning

confidence: 99%

Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

et al. 2016

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“…The relative efficacy of modafinil is further supported in a study conducted by the United States Air Force in comparing dextroamphetamine to modafinil in the ability of the respective drugs to counter the debilitating mood and Physiology & Behavior 142 (2015) 126-130 cognitive effects of sleep loss during long-term operations [5]. Both drugs were found to be effective in this regard.…”

Section: Introductionmentioning

confidence: 92%

“…Amphetamine, a wellknown psychostimulant, does not share a similar pharmacological profile when compared to modafinil [3]. Modafinil is different from dextroamphetamine (Adderall) in one major aspect; modafinil shows a low affinity for dopamine (DA) uptake binding sites [5].…”

Section: Introductionmentioning

confidence: 99%

Modafinil as a cognitive enhancer of spatial working memory in rats

Murphy

Ekstrand

Tarchick

et al. 2015

Physiology & Behavior

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“…Its strongest endorsement comes from the military [227] and astronautics [228]. In the United States military, modafinil has been approved for use on certain Air Force missions [229][230][231] as an adjunct to fight fatigue. It has been approved for use aboard the International Space Station where it helps with the disruptions in circadian rhythms and the reduced quality of sleep that astronauts experience [228].…”

Section: Nootropicsmentioning

confidence: 99%

The Speculative Neuroscience of the Future Human Brain

Dielenberg¹

2013

Humanities

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Abstract:The hallmark of our species is our ability to hybridize symbolic thinking with behavioral output. We began with the symmetrical hand axe around 1.7 mya and have progressed, slowly at first, then with greater rapidity, to producing increasingly more complex hybridized products. We now live in the age where our drive to hybridize has pushed us to the brink of a neuroscientific revolution, where for the first time we are in a position to willfully alter the brain and hence, our behavior and evolution. Nootropics, transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS) and invasive brain mind interface (BMI) technology are allowing humans to treat previously inaccessible diseases as well as open up potential vistas for cognitive enhancement. In the future, the possibility exists for humans to hybridize with BMIs and mobile architectures. The notion of self is becoming increasingly extended. All of this to say: are we in control of our brains, or are they in control of us?

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Modafinil as a Replacement for Dextroamphetamine for Sustaining Alertness in Military Helicopter Pilots

Cited by 76 publications

References 20 publications

Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

Modafinil Induces Rapid-Onset Behavioral Sensitization and Cross-Sensitization with Cocaine in Mice: Implications for the Addictive Potential of Modafinil

Modafinil as a cognitive enhancer of spatial working memory in rats

The Speculative Neuroscience of the Future Human Brain

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