Modalities of testing<i>Helicobacter pylori</i>in patients with nonmalignant bile duct diseases

Bulajić, Milutin; Štimec, Bojan; Milicevic, Mladen; Loehr, Matthias; Mueller, Petra; Boričić, Ivan; Kovačević, Nada; Bulajić, Milica

doi:10.3748/wjg.v8.i2.301

Cited by 21 publications

(14 citation statements)

References 17 publications

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“…Our literature search identified 20 studies investigating the presence of Helicobacter species in the bile, gallstones, or BT tissue biopsies of patients with benign BT diseases (Arnaout et al, 1990;Figura et al, 1998;Fox et al, 1998;Monti et al, 1999;Rudi et al, 1999;Myung et al, 2000;Harada et al, 2001;MendezSanchez et al, 2001;Monstein et al, 2002;Roosendaal et al, 2002;Bulajic et al, 2002b;Chen et al, 2003Chen et al, , 2007Silva et al, 2003;Farshad et al, 2004;Abayli et al, 2005;Apostolov et al, 2005;Neri et al, 2005;Tiwari et al, 2006;Misra et al, 2007). Of these, 19 used PCR amplification methods (Table 3).…”

Section: Helicobacter Species and Benign Bt Diseasesmentioning

confidence: 99%

Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

et al. 2008

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Helicobacter species have been found in human bile and biliary tract (BT) tissue and are suspected to cause BT diseases, including gallbladder and extrahepatic cancers, collectively referred to in this work as BT cancers. We conducted a literature review of the epidemiological evidence linking the presence of Helicobacter species in bile or BT biopsies to BT cancers and benign diseases. Reports showed great variability with respect to study methods. Nine studies of BT cancers were identified, all with 30 or fewer BT cancers; eight included cancer-free control subjects and used polymerase chain reaction (PCR) as a means of Helicobacter species detection. In four of these studies, Helicobacter species were detected in patients with BT cancer significantly more frequently than in controls, at least when controls without BT diseases were used. In two studies, no Helicobacter species were detected in either cases or controls. Helicobacter species were also often detected in benign BT diseases such as gallstone disease or chronic cholecystitis. As our current knowledge relies on a few small studies that showed substantial differences, larger studies and more standardised protocols for detecting DNA and antibodies against Helicobacter species are needed to investigate a potential association with BT cancer.

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Section: Helicobacter Species and Benign Bt Diseasesmentioning

confidence: 99%

Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

et al. 2008

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“…or H. pylori DNA was detected in bile and or gallbladder tissue from patients with benign or malignant biliary diseases [9]. In contrast, other authors did not detect any Helicobacter DNA in the biliary trees of patients with the same diseases [10]. The role of Helicobacter in the pathogenesis of gallbladder disease in humans, or even its presence in gallbladder tissue, therefore remains unclear.…”

Section: Introductionmentioning

confidence: 98%

Presence of Helicobacter spp. DNA in the gallbladder of Egyptian patients with gallstone diseases

Ghazal

Sabbagh²,

Riwini³

2011

East Mediterr Health J

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Earlier reports on the detection of Helicobacter DNA in the gallbladder tissue of patients with biliary diseases have shown discordant results. This study aimed to detect the presence of Helicobacter in gallstone, gallbladder tissue and bile specimens from subjects with H. pylori-positive gastritis with cholelithiasis. The presence of H. pylori in antrum biopsies was confirmed by rapid urease test and/or histopathological examination. DNA was extracted from gallbladder, bile and gallstone samples from 50 patients undergoing cholecystectomy. The presence of Helicobacter genus-specific DNA (16S rRNA genes) was determined by nested polymerase chain reaction assay. Helicobacter DNA was detected in the gallbladder tissue and bile of 28% and 18% respectively of the patients, but was not detected in any of the gallstones. These results do not rule out the possibility of Helicobacter infection as a contributing agent or cofactor in the development of biliary diseases.

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“…Despite these findings, there are also studies that could find no such association between H. pylori and hepatobiliary diseases (8)(9)(10).…”

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confidence: 95%

Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis

Bostanoğlu

Karahan²,

Bostanoğlu³

et al. 2010

Turk J Gastroenterol

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Modalities of testingHelicobacter pyloriin patients with nonmalignant bile duct diseases

Cited by 21 publications

References 17 publications

Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract

Presence of Helicobacter spp. DNA in the gallbladder of Egyptian patients with gallstone diseases

Evaluation of the presence of Helicobacter species in the biliary system of Turkish patients with cholelithiasis

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