Mode of delivery at birth and development of asthma: A population-based cohort study

Juhn, Young J.; Weaver, Amy L.; Katusic, Slavica K.; Yunginger, John W.

doi:10.1016/j.jaci.2005.05.043

Cited by 81 publications

(56 citation statements)

References 55 publications

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“…Likewise, we observed caesarean mode of delivery was found significantly associated with asthma risk, as reported earlier also [45,46]. Unlike these studies, some studies have reported that mode of delivery is not associated with subsequent risk of developing childhood asthma or wheezing episodes [47,48].…”

Section: Discussionsupporting

confidence: 86%

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

Dixit¹,

Awasthi²,

Maurya³

et al. 2013

Ind J Clin Biochem

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Cystic Fibrosis Trans membrane conductance regulator (CFTR) gene is an asthma susceptibility gene. In the present study we investigated the possible association of CFTR gene mutations in Indian asthmatic children as compared to controls. The study included 250 asthmatics and 250 age and sex matched controls. Case to control ratio for sample size was 1:1. Genotyping was performed for 24 CFTR gene mutations by ARMS-PCR and PCR-RFLP method. Among 24 CFTR gene mutations, heterozygous allele of R553X mutation was found in 4 (1.6 %) asthmatic cases and 2 (0.8 %) controls. Value of FVC and FEV1/ FVC ratio were significantly lower in heterozygous individuals (p value \0.05). No significant difference was observed in the genotype and allele frequency of R553X mutation (OR = 1.339, 95 % CI = 0.755-2.374, p value = 0.685). Furthermore, all wild type homozygous alleles were observed in remaining 23 CFTR gene mutations. Our data concludes that R553X mutation was not significantly associated in Indian asthmatic children.

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Section: Discussionsupporting

confidence: 86%

CFTR Gene Mutations and Asthma in Indian Children: A Case–Control Study

Dixit¹,

Awasthi²,

Maurya³

et al. 2013

Ind J Clin Biochem

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“…However, besides allergens, early-life risk factors have rarely been related to rhinitis (250,251). Young maternal age, markers of fetal growth (42, [252][253][254], multiple gestation (255)(256)(257), mode of delivery (258)(259)(260)(261)(262), prematurity (263), low birth weight (264,265), growth retardation (265), hormones during pregnancy (266) and perinatal asphyxia (263) were all inconstantly related to the risk of developing allergic diseases or rhinitis. As a consequence, existing results are contradictory and require confirmation.…”

Section: Early-life Risk Factorsmentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,861

1,761

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“…The entire medical records of both patients in the cases and of the controls were reviewed to determine the presence of asthma by applying predetermined asthma criteria (PAC), which is delineated in Table 1. These criteria have been extensively used in previous studies of asthma epidemiology [15][16][17][18][19][20][21][22][23][24][25] and were found to have high reliability. 26 In addition to determining asthma status, we also evaluated for asthma characteristics, including medication use, asthma control, risk factors for asthma, and other atopic conditions.…”

Section: Selection Of Non-cd Controlsmentioning

confidence: 99%