Mode of delivery is not associated with celiac disease

Sander, Stine Dydensborg; Hansen, Anne Vinkel; Størdal, Ketil; Andersen, Anne‐Marie Nybo; Murray, Joseph A.; Husby, Steffen

doi:10.2147/clep.s152168

Cited by 31 publications

(20 citation statements)

References 36 publications

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“…23 Previous studies have suggested that the risk of CID is higher for elective than for acute section. 27,33 Whereas our study has confirmed an increased risk for both acute and elective section, our data is too limited to test for any possible differential risk in the two modes of CS, although the overall estimate is higher for elective CS.…”

Section: Discussionmentioning

confidence: 52%

“…Large nation-wide populations based studies have evaluated whether the risk of CIDs was increased in CS compared to vaginal delivery. 22,28,33,34 First, an increased risk of IBD was found among 2 mio. children in the Danish population (1973-2008 and 1977-2009, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…21 In contrast to planned CS (elective CS), acute CS will often be performed after initiation of the labour, where an open birth canal might potentially give access to the vaginal microbial community. Studies have addressed the risk of developing IBD, [22][23][24][25][26][27] DM, [27][28][29][30] CD, [31][32][33] and RA. 34 CS, and in particular elective CS has been associated with risk of CIDs in some studies, 22,24,27,32 but not all.…”

Section: Introductionmentioning

confidence: 99%

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<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Andersen¹,

Möller²,

Jensen³

et al. 2020

CLEP

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Background: Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases. Methods: A national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents' chronic inflammatory disease status was used. Results: This register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease. Conclusions: Being born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Andersen¹,

Möller²,

Jensen³

et al. 2020

CLEP

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show abstract

“…A large registry-based cohort study that included over 1.5 million children from Denmark and Norway found no association between the mode of delivery (cesarean section vs. vaginal birth) and the risk of diagnosed CD (43). Data collected from the same cohort indicated that exposure to systemic antibiotics in the first year of life was positively associated with diagnosed CD, with a dose-dependent relation between an increasing number of dispensed antibiotics and CD risk (44).…”

Section: Early Eventsmentioning

confidence: 98%

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

et al. 2020

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Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.

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“…Similarly, large observational studies found no link between c-section and CeD development ( 49 , 69 , 79 ). Finally, a large register-based study, that included children from two independent cohorts, found that birth delivery mode was not associated with increased risk of diagnosed CeD ( 51 ). Although the data is conflicting, the potential links between early events that can alter the microbiota composition, such as antibiotic use or birth delivery mode, and later CeD implicate a role of the microbiome in disease development.…”

Section: The Role Of Environment In Disease Developmentmentioning

confidence: 99%

Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies

2018

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Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. Although the inflammatory lesion of celiac disease is complex, the strong HLA association highlights a central role for pathogenic T cells responding to select gluten peptides that have now been defined for the most common genetic form of celiac disease. What remains less understood is how loss of tolerance to gluten occurs. New insights into celiac disease are now providing opportunities to intervene in its development, course, diagnosis, and treatment.

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Mode of delivery is not associated with celiac disease

Cited by 31 publications

References 36 publications

<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies

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