Model‐based analysis of multishell diffusion MR data for tractography: How to get over fitting problems

Jbabdi, Saâd; Sotiropoulos, Stamatios N.; Savio, Alexander M.; Graña, Manuel; Behrens, Timothy E.J.

doi:10.1002/mrm.24204

Cited by 376 publications

(350 citation statements)

References 46 publications

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“…To evaluate white matter microstructural integrity, DTI data was processed using FSL-TBSS (tract-based spatial statistics) [48,49] analysis. The procedure uses an algorithm described in Agosta et al [50].…”

Section: Analysis Of Structural Imaging Datamentioning

confidence: 99%

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

et al. 2015

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Section: Analysis Of Structural Imaging Datamentioning

confidence: 99%

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

et al. 2015

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“…[6][7][8]22,23 Diffusion volumes were corrected for both eddy currents and motion. The diffusion tensor was then calculated for each voxel with a least-squares fit to the log of the diffusion signal.…”

Section: Acquisition and Processing Of Mri Datamentioning

confidence: 99%

Postshunt lateral ventricular volume, white matter integrity, and intellectual outcomes in spina bifida and hydrocephalus

Williams

Juranek²,

Stuebing

et al. 2015

PED

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OBJECT No previous reports exist that have evaluated the relationships of white matter (WM) integrity with the number of shunt revisions, ventricular volume after shunting, and cognition in medically stable children who have spina bifida and hydrocephalus (SBH). The authors hypothesized that enlarged ventricles and a greater number of shunt revisions decrease WM integrity in children. METHODS In total, 80 children (mean age 13.7 years) who had SBH underwent MRI and IQ testing. Probabilistic diffusion tractography was performed to determine mean diffusion tensor imaging (DTI) metrics along the frontal and parietal tectocortical pathways. The DTI metrics were evaluated for significant correlation with a composite IQ measure and with the total number of shunt revisions and the total lateral ventricular volume obtained through semiautomated parcellation of T1-weighted MRI scans. RESULTS An enlargement in total lateral ventricle volume and an increase in the number of shunt revisions were both associated with higher fractional anisotropy (FA) and with lower radial diffusivity (RD) along both frontal and parietal tectocortical pathways. Children who had not undergone a shunt revision had on average a greater lateral ventricle volume and higher FA and lower RD along frontal and parietal pathways than those who had undergone multiple shunt revisions. The mean DTI metrics along parietal pathways predicted IQ scores, but intellectual ability was not significantly correlated with ventricular volume or with the number of lifetime shunt revisions. CONCLUSIONS Significant changes in DTI metrics were observed as a function of ventricular volume. An increased lateral ventricle volume was associated with elevated FA and decreased RD. Given that the participants were medically stable at the time of the MRI examination, the results suggested that those who have enlarged ventricles show a DTI pattern consistent with axonal compression due to increased intracranial pressure (ICP) in attenuated hydrocephalus. Although limited by a cross-sectional design, the study's findings suggest that DTI metrics may serve as sensitive indicators for chronic, mild hydrocephalus in the absence of overt clinical symptoms due to increased ICP. Having enlarged ventricles and undergoing multiple shunt revisions did not affect intellectual ability in children with SBH.

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“…The FMRIB Diffusion Toolbox (http://www.fmrib.ox.ac.uk/fsl/ fdt/index.html) 21 was used to perform preprocessing of brain and spinal cord DTI datasets. Distortion correction was first performed to remove eddy currents and motion artifacts.…”

Section: Mr Image Preprocessingmentioning

confidence: 99%

Variation in Anisotropy and Diffusivity along the Medulla Oblongata and the Whole Spinal Cord in Adolescent Idiopathic Scoliosis: A Pilot Study Using Diffusion Tensor Imaging

Kong

Shi

Hui

et al. 2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Disturbed somatosensory evoked potentials have been demonstrated in patients with adolescent idiopathic scoliosis (but this functional delay was found to originate above the C5-6 level, while the lower cord level was unaffected). Together with MR imaging observation of tonsillar ectopia and a relatively tethered cord, we hypothesized that there is disturbed mean diffusivity integrity along the spinal cord. In this study, advanced DTI was used to evaluate whether there was underlying decreased WM integrity within the brain stem and spinal cord in adolescent idiopathic scoliosis and any relationship to cerebellar tonsillar ectopia. Clinical impact on balance testing was also correlated.

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Model‐based analysis of multishell diffusion MR data for tractography: How to get over fitting problems

Cited by 376 publications

References 46 publications

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

Increased connectivity between sensorimotor and attentional areas in Parkinson’s disease

Postshunt lateral ventricular volume, white matter integrity, and intellectual outcomes in spina bifida and hydrocephalus

Variation in Anisotropy and Diffusivity along the Medulla Oblongata and the Whole Spinal Cord in Adolescent Idiopathic Scoliosis: A Pilot Study Using Diffusion Tensor Imaging

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