Model-based equipment-design for plant-based extraction processes – considering botanic and thermodynamic aspects

Both, Simon; Koudous, I.; Jenelten, Urban; Strube, Jochen

doi:10.1016/j.crci.2013.11.004

Cited by 15 publications

(16 citation statements)

References 26 publications

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“…The scope of this article is to introduce the reader to a modern process engineering attempt for the manufacturing of traditionally used herbal extracts including physico-chemical process modelling and experimental parameter determination on lab-scale. The benefits of the modelling and simulation approach for phytoextraction are documented in detail by various studies of the authors [5,6,[14][15][16][17][18][19][20][21][22][23]. The cited articles focused mostly on the extraction of valuable compounds for plants in order to perform a further purification until a pure substance in pharma-grad is obtained, e.g., for 10-deacetylbaccatin III from yew [6,18] or artemisinin from annual mugworth [5].…”

Section: Resultsmentioning

confidence: 99%

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Sixt

Strube

2018

Processes

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Traditionally used herbal medicines are deep in the consciousness of patients for the treatment of only minor diseases by self-medication. However, manufacturers of herbal medicinal products suffer from major problems such as increasing market pressure by e.g., the food supplement sector, increasing regulations, and costs of production. Moreover, due to more stringent regulation and approval processes, innovation is hardly observed, and the methods used in process development are outdated. Therefore, this study aims to provide an approach based on modern process engineering concepts and including predictive process modelling and simulation for the extraction of traditional herbal medicines as complex extracts. The commonly used solvent-based percolation is critically assessed and compared to the so-called pressurized hot water extraction (PHWE) as a new possible alternative to replace organic solvents. In the study a systematic process design for the extraction of hawthorn (Crataegus monogyna JACQ.) is shown. While for traditional percolation the solvent is optimized to a mixture of ethanol and water (70/30 v/v), the PHWE is run at a temperature of 90 • C. The extracts of various harvest batches are compared to a commercially available product based on a chromatographic fingerprint. For the first time, natural batch variability was successfully incorporated into the physico-chemical process modelling concept. An economic feasibility study reveals that the PHWE is the best choice not only from a technical point of view but also from economic aspects.

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Section: Resultsmentioning

confidence: 99%

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Sixt

Strube

2018

Processes

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“…The overall amount of each considered component is determined by means of an exhaustive percolation and Equation (21). Where q max is the loading of the plant material with the respective component, c Comp the concentration in the extract, V Extract the extract volume and m Plant the amount of plant material used.…”

Section: Overall Amountmentioning

confidence: 99%

“…These studies, based on pepper and vanilla, predict influences of different particle diameters, solid/liquid ratios, and residence times. Both et al [18][19][20][21] extended the validation on sugar and tea for different process concepts like maceration and percolation, recycling-mode percolation, as well as different residence times and solid/liquid ratios. They even showed the scale independent validity of the model by means of a scale up industrial level study for the extraction of sugar beet [18].…”

Section: Introductionmentioning

confidence: 99%

Toward a Distinct and Quantitative Validation Method for Predictive Process Modelling—On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts

2018

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Physico-chemical modelling and predictive simulation are becoming key for modern process engineering. Rigorous models rely on the separation of different effects (e.g., fluid dynamics, kinetics, mass transfer) by distinct experimental parameter determination on lab-scale. The equations allow the transfer of the lab-scale data to any desired scale, if characteristic numbers like e.g., Reynolds, Péclet, Sherwood, Schmidt remain constant and fluid-dynamics of both scales are known and can be described by the model. A useful model has to be accurate and therefore match the experimental data at different scales and combinations of process and operating parameters. Besides accuracy as one quality attribute for the modelling depth, model precision also has to be evaluated. Model precision is considered as the combination of modelling depth and the influence of experimental errors in model parameter determination on the simulation results. A model is considered appropriate if the deviation of the simulation results is in the same order of magnitude as the reproducibility of the experimental data to be substituted by the simulation. Especially in natural product extraction, the accuracy of the modelling approach can be shown through various studies including different feedstocks and scales, as well as process and operating parameters. Therefore, a statistics-based quantitative method for the assessment of model precision is derived and discussed in detail in this paper to complete the process engineering toolbox. Therefore a systematic workflow including decision criteria is provided.

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“…Chemical characterization of raw plant material -determination of moisture, water and 10-DAB Product moisture is an important and technologically relevant parameter in the extraction process of taxanes either for determination of needed amounts of solvent or for the overall adjustment of the process [23,24]. Near infrared spectroscopy (NIRS) was employed for moisture prediction in the raw yew material by correlation with weighting of dry matter as reference method.…”

Section: Characterization Of the Raw Plant Materialsmentioning

confidence: 99%

Infrared and Raman spectroscopic methods for characterization of Taxus baccata L. – Improved taxane isolation by accelerated quality control and process surveillance

Gudi

Krähmer

Koudous

et al. 2015

Talanta

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Model-based equipment-design for plant-based extraction processes – considering botanic and thermodynamic aspects

Cited by 15 publications

References 26 publications

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Toward a Distinct and Quantitative Validation Method for Predictive Process Modelling—On the Example of Solid-Liquid Extraction Processes of Complex Plant Extracts

Infrared and Raman spectroscopic methods for characterization of Taxus baccata L. – Improved taxane isolation by accelerated quality control and process surveillance

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