Real-time monitoring of tire wear is a hot spot in the research of automobile tires, and it has a great significance to ensure the safety of automobile driving. A tire wear estimation algorithm was proposed based on the relevant knowledge of finite element modal analysis theory and the concept of intelligent tires in this paper. First, the finite element model of the 205/55/R16 radial tire was established through the ABAQUS software, then the finite element method was used to simulate and analyze the influence of tire inflation pressure, load, tire wear, and speed on the tire radial vibration frequency. The simulation results show that inflation pressure and tire wear shows an upward trend with the increase of the vibration frequency of each order in the tire radial direction, and load and speed increase with what increases of tire radial increase frequency. Based on simulation analysis data, combined with the relationship between tire inflation pressure, load, tire wear, speed, and radial vibration frequency, a neural network-based tire wear estimation algorithm is proposed. The estimate results show that the predicted wear curve and the actual wear curve have a higher degree of overlap, the average error is 0.0874 mm, and the average error percentage is 2.78%, Thus, a feasible tire wear estimation algorithm is proposed.