“…After consulting the data, it is found that the reactor has the characteristics of strong time-delay, time-varying, and nonlinear. If viewed from a micro perspective, it would inevitably cause great difficulties to the experiment, so it is much easier to describe the whole process from a macro perspective starting from the law of heat conservation [Eypasch, Schimpe, Kanwar et al (2017); Gokon, Kumaki, Miyaguchi et al (2019)]. The establishment of heat transfer model cannot be separated from the estimation of parameters, and the essence of parameter optimization estimation is the problem of nonlinear least square method [Han, Hagos, Ji et al (2016)].…”