Uplift pressure is an important factor for dam stability. The simulation of uplift pressure in dam model test is, however, still an unsolved problem. This paper presents original developments in uplift pressure simulation including mechanical analysis, theoretical derivations, numerical simulation and experimental investigation. Based on the loading properties, a new test method for simulating uplift pressure by equivalent loads is proposed, and relevant calculation formulas are derived. Similarity theory was used to deduce the similarity relations. Numerical analyses of two dams were carried out, and the equivalence, similarity and applicability of the equivalent simulation method were verified. Finally, this method was applied in the model test of a practical dam. Sound test results were obtained, which have been adopted in the design and construction of the dam. Research results show that the equivalent simulation method is a feasible test method for simulating the effects of the uplift pressure in model tests.