Model of an Antithrombogenic Surface of a Solid

Baurschmidt, P.; Thulĺ, R.; Schaldach, M.

doi:10.1007/978-3-642-66471-7_27

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Studies by Schaldach and co-workers demonstrated that the interaction of an implant to the surrounding physiological fluid, cells, or tissues could be reduced by a low transfer current density. 23,24 By imposing a small ac voltage and by varying the frequency during the measurement, the properties of the oxide films on the MP35N wires in an electrolyte solution, such as capacitance and resistance, were measured. The purpose of this experiment was to simulate the implant condition and characterize the various passivated surfaces to distinguish their reaction to electrolyte at OCP.…”

Section: Discussionmentioning

confidence: 99%

Electrochemical Behavior of MP35N Implant Alloy in Simulated Physiological Media

Shih¹,

Shih

Chou

et al. 2006

J. Electrochem. Soc.

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For years, MP35N alloy has been regarded as a very high corrosion-resistant material and has been widely used in various medical applications such as orthopedic implants, lead wire for pacemakers, and cardiovascular stents. Previous researchers of this alloy revealed corrosion pits or localized oxidation on the surface of this material after exposure to Ringer's solution. Therefore, a detailed examination of this multiphase alloy was designed to understand its electrochemical properties and to explore its corrosion behavior. Corrosion resistance of MP35N was investigated by open-circuit potential, anodic polarization, potentiostatic control, electrochemical impedance spectroscopy, and linear voltammetry techniques. Compositional studies of oxide film were examined by electron spectroscopy for chemical analysis. Surface morphologies of MP35N after electrochemical studies were characterized by scanning electron spectroscopy. Elemental distribution and chemical composition was identified by energy dispersive spectrum. Results indicate that chemical composition of the oxide film after passivation plays an important role in the determination of corrosion resistance of MP35N in Ringer's solution. A high concentration of hydroxyl and hydrate groups inside the passivated oxide film is beneficial to the corrosion resistance of this multiphase alloy.

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Section: Discussionmentioning

confidence: 99%

Electrochemical Behavior of MP35N Implant Alloy in Simulated Physiological Media

Shih¹,

Shih

Chou

et al. 2006

J. Electrochem. Soc.

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“…2,15 Several researchers reported that the process of clotting, where fibrinogen is activated by cleavage of a propeptide by thrombin into fibrin, can be inhibited when similar semiconducting properties between the surface and blood proteins are achieved. 2,14,15,36 In our experimental results, SiC single crystals did not exhibit the expected hemocompatibility levels despite the fact that they have the most appropriate Fermi energy level that can inhibit fibrinogen activation compared to Al 2 O 3 single crystals. Nevertheless, it is worth to further investigate these materials since they showed significantly lower platelet activation than that of glass.…”

Section: Discussionmentioning

confidence: 74%

“…The interaction mechanism between fibrinogen molecules and the material surface leads to the discharge of the fibrinopeptides and in consequence clotting by the change of charge distribution. In order to prevent the activation of the blood proteins, the charge transfer on the surface must be avoided, as theoretically explained in the literature. , …”

Section: Introductionmentioning

confidence: 99%

“…In order to prevent the activation of the blood proteins, the charge transfer on the surface must be avoided, as theoretically explained in the literature. 14,15 In order to understand the above-mentioned interactions, we examined the endothelialization quality, toxicity, and blood cell responses for (0001) and (11−20) planes of Al 2 O 3 single crystals. Cytocompatibility of the specimens was analyzed by live/dead stainings for both HUVEC and blood cells.…”

Section: Introductionmentioning

confidence: 99%

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Toward Innovative Hemocompatible Surfaces: Crystallographic Plane Impact on Platelet Activation

Parlak

Labude

Rütten

et al. 2020

ACS Biomater. Sci. Eng.

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The anticoagulation treatment of cardiovascular patients, which is mandatory after implantation of heart valves or stents, has significantly adverse effects on life quality. This treatment can be reduced or even circumvented by developing novel antithrombogenic surfaces of blood-contacting implants. Thus, we aim to discover materials exhibiting outstanding hemocompatibility compared to other available synthetic materials. We present promising surficial characteristics of single crystalline alumina in terms of platelet activation inhibition. In order to elucidate the relation between its crystallographic properties including the plane orientation and blood cell behavior, we examined endothelialization, cytocompatibility, and platelet activation at the blood-alumina interfaces in a controlled experimental setup. We observed that the cell response is highly sensitive to the plane orientation and differs significantly for (0001) and (11–20) planes of Al2O3. Our results reveal for the first time the dependence of platelet activation on crystallographic orientation, which is assumed to be a critical condition controlling the thrombogenicity. Additionally, we used an endothelial cell monolayer as an internal control since endothelial cells have an impact on vessel integrity and implant acceptance. We successfully demonstrate that Al2O3(11–20) exhibits enhanced hemocompatibility in contrast to Al2O3(0001) and is comparable to the physiological endothelial monolayer in vitro.

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“…Platelet response following the contact of blood with an artificial surface is also influenced by diffusion and shear forces. Several authors report the close interaction of platelets and the electron transfer from the biomaterial surface [73,74]: By reducing the density of states (the number of states at an energy level that are available to be occupied) in the corresponding energy region of fibrinogen, clotting of platelets can be reduced by inhibiting its polymerization to fibrin.…”

Section: Blood Cellsmentioning

confidence: 99%

Inorganic PVD and CVD Coatings in Medicine — A Review of Protein and Cell Adhesion on Coated Surfaces

Lackner

Waldhauser

2010

Journal of Adhesion Science and Technology

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The functionalization of biomaterials for implants becomes increasingly important for designing bioinert and bioactive surfaces to reduce the impact of implantation to human body (inflammation, encapsulation) and extend the lifetime of implants. Even pharmacological effects can be triggered by nanomaterials like thin films and nanoparticles in medical treatment. However, the systematic knowledge of the interactions between cells and artificial, inorganic materials is poor yet. Finding the decisive influences for high hemocompatibility or osseointegration is very difficult. Surface chemistry including wetting behaviour, surface charge, homogeneity and functional groups as well as surface topography are some of the fundamental surface parameters defining the cell-surface interaction. Focusing on physical and chemical vapour deposited thin films and coatings, this review will provide for a better understanding of biocompatible coating materials like titanium-and carbon-based compounds and calcium phosphates. of the main goals of biomaterials research [3,4]. However, the precise mechanisms involved in this cell-surface and protein-surface interactions are still unknown.Generally, surfaces of synthetic biomaterials (e.g., polymers, metals and ceramics) are not bioactive themselves. Rather, surface bioactivity is provided by the proteins that adsorb to the biomaterial surface following exposure of the surface to biological fluids. The first molecules are water molecules reaching the surface in a biological milieu containing cells. When cells arrive at the surface, they 'see' a protein-covered surface whose bioactive protein layer has properties that were initially determined by the pre-formed water shells. To control cellular response, it is important to first understand how surface chemistry, surface topography and mechanical forces influence the formation of the adsorbed protein layer and the bioactive sites presented by this layer. Besides water, proteins and cells, biological model systems for biointerfaces (or surfaces) must contain amino acids, nucleic acids and lipids, peptides and DNA (segments), and tissue to describe the sequences occurring in the human body [5]. The recognition of these molecular-scale features is programmed into the molecules through the combination of their 3-D topographic architecture, the superimposed chemical architecture, and the dynamic properties [5]. Although the fundamental interactions occur on the molecular scale, there is an interesting and unique synergistic connection between the nanometer and the micrometer length scales [6-8], when cells are present.Recent advances in topographical surface modification techniques such as electron beam lithography [9], photolithography [10], colloidal lithography [11,12], laser ablation [13] and polymer demixing [14] have allowed the fabrication of surfaces with nano-sized features. In addition, the modification of the surface chemistry by coating with biomaterials or biomolecules of 'higher biocompatibility' helps to separate between bulk pr...

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Model of an Antithrombogenic Surface of a Solid

Cited by 6 publications

References 4 publications

Electrochemical Behavior of MP35N Implant Alloy in Simulated Physiological Media

Electrochemical Behavior of MP35N Implant Alloy in Simulated Physiological Media

Toward Innovative Hemocompatible Surfaces: Crystallographic Plane Impact on Platelet Activation

Inorganic PVD and CVD Coatings in Medicine — A Review of Protein and Cell Adhesion on Coated Surfaces

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