Model of nonalcoholic steatohepatitis

Abstract

This rat model reproduces the key features of human NASH and provides a realistic experimental model for elucidating its treatment.

Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats

“…Zucker diabetic fatty rats, a model of obesity secondary to genetic leptin unresponsiveness, rapidly accumulated triglycerides in the heart, which was accompanied by left ventricular remodeling and septal wall thickening [28] . Regarding the liver, many studies in mice [7] and rats [29] have documented high-fat diet induced fat accumulation in the liver and hepatic steatosis. These findings demonstrate that a high-fat diet may promote triglyceride accumulation in non-adipose tissues; the results of the present study convincingly show that a high-fat lard diet increased thyroid triglyceride content.…”

High Fatty Diet Effects on Rat Liver

“…In some studies about high -fat diet, corn oil was used as the content of the high-fat diet and the negative effects such as liver steatosis, inflammation were observed (17,18). Corn oil includes 24.1% oleic acid, 61.9% linoleic acid, 11% palmitic acid, 2% stearic acid and linolenic acid 0.07% (19) and linoleic acid (omega-6) has inflammatory, thrombotic, mitogenic and hyperalgesic effects (20).…”

Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease

“…Experimental models based on voluntary food intake have been developed to induce hepatic steatosis in laboratory animals [2][3][4][5][6][7][8]. The nutritional models using complete diets resemble the human condition in that they contain amounts of lipids or carbohydrates that exceed the energy needs of the body.…”