Model simulation of an efficient periodic control strategy for continuous fermentation processses

Abstract

Simulation experiments of a periodic control regime for continuous fermentation processes are described. They are carried out with a state-structure model on the basis of a system of delaydifferential equations. The perception of a fermentation system as an ecosystem leads to new and informative results which are to be applied to the development of efficient periodic control strategies.

Dynamic process conditions in bioprocess development

“…Early experiments using oscillating conditions for bioprocess development can already be found in the 1980s and 1990s , e.g. when Larsson and Enfors applied oxygen oscillation on P. chrysogenum to analyse effects on the respiratory quotient and the metabolism .…”

“…2), and subsequently developed feeding strategies based thereon (see 2.1.1). We successfully applied 2 Production kinetics [113] dO 2 , substrate Metabolism, amino acid pool [7] pH Expression of stress response genes, viability [115] Production of alarmone [114] Substrate Productivity, product quality [116] Enrichment of production host [117][118][119][120][121] Eukaryotes dO 2 Productivity, metabolite formation [122,123,125] Light Biomass production, photosynthesis [51] C-and P-source Heat production, q s [16,108] dO 2 Productivity [124] this fast dynamic strain characterisation method to different genomic modified yeast strains expressing different recombinant proteins [40,107].…”