Due to the increasing quest of adopting low-cost sensors in structural health monitoring (SHM) processes, which may lead to detecting signals contaminated by significant levels of noise, the need to devise appropriate and effective denoising strategies, at the post-processing stage, is becoming more and more essential. Among several approaches proposed in the literature, it has been demonstrated that the employment of discrete wavelet transform (DWT) as a multi-rate filter bank, as well as the use of singular value decomposition (SVD), may result to be quite effective in signal denoising within various research fields, as biological, acoustic and mechanical. Here, DWT- and SVD-based denoising techniques are first independently reconsidered and reimplemented, aiming at exploring their optimal calibration in purifying noise-corrupted vibration response signals encountered in civil engineering applications. Then, a systematic performance evaluation is provided within a comparative framework, developed at an increasing level of noise affecting the measurements, in terms of noise-to-signal (N/S) ratio. In the study, two specific classes of synthetic response signals are first considered, namely earthquake and ambient vibration signals, since they may be assumed as representative of more general non-stationary and stationary signal typologies, respectively. To achieve a complete description of the clarified signal, strengths and weaknesses of the two denoising approaches are explored, in both time and frequency domains. The results prove the effectiveness of the analyzed implementations, especially in purifying seismic response signals, while some limitations may arise concerning the treatment of ambient vibration signals, in particular for the DWT-based denoising technique. Finally, a real case study is analyzed, where both denoising approaches are adapted and employed for clarifying acceleration signals detected on a modern short-span railway bridge, with rather satisfactory results, for both techniques.