The paper is part of a case study concerning the structural assessment of a historical infrastructure in the local territory, a road three-span reinforced concrete arch bridge over a river, built by the end of World War I (1917). The purpose of the paper is twofold: first, in-situ acquired response data are systematically analysed by specific signal processing techniques, to form a devoted methodological procedure and to extract useful information toward possible interpretation of the current structural conditions; second, the deciphered information is elaborated, in view of obtaining peculiar conceptualisations of detailed features of the structural response, as meant to achieve quantitative descriptions and modelling, for final Structural Health Monitoring (SHM) and intervention purposes. The proposed methodology, integrating self-implemented and adapted classical signal processing methods, and refined techniques, such as Wavelet analysis and ARMA models, assembles a rather general, systematic methodological approach to signal processing, highlighting the capability to extract useful and fundamental information from acquired response data, also endowed of a non-stationary character, toward final structural interpretation, identification and modelling, thus enabling for developing a reliable and effective SHM platform, on strategic ageing infrastructures. For the present case study, non-stationary characteristics of the response signals are revealed and flattened out, to identify the underlying fundamental frequencies of the infrastructure and to advance particular interpretations of its current structural behaviour, informing an enlarging structural consciousness of the bridge at hand.