Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with joule heating, viscous dissipation and variable viscosity effects

Gandhi, Rishu; Sharma, B. K.; Kumawat, Chandan; Bég, O. Anwar

doi:10.1177/09544089221080273

Cited by 55 publications

(13 citation statements)

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“…The optimization of solar energy using Sutterby hybrid nanofluid in solar HVAC subjected to expanding sheets was also addressed by Jamshed et al [ 13 ]. Recently, some research ([ 14 , 15 , 16 , 17 ]) has examined the effect of nanoparticles in different types of fluids. A comparison of thermal characteristics of Cu and Ag nanoparticle suspensions in sodium alginate for Sutterby nanofluid flow in solar collectors was conducted by Bouslimi et al [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Entropy Generation and Thermal Radiation Analysis of EMHD Jeffrey Nanofluid Flow: Applications in Solar Energy

et al. 2023

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This article examines the effects of entropy generation, heat transmission, and mass transfer on the flow of Jeffrey fluid under the influence of solar radiation in the presence of copper nanoparticles and gyrotactic microorganisms, with polyvinyl alcohol–water serving as the base fluid. The impact of source terms such as Joule heating, viscous dissipation, and the exponential heat source is analyzed via a nonlinear elongating surface of nonuniform thickness. The development of an efficient numerical model describing the flow and thermal characteristics of a parabolic trough solar collector (PTSC) installed on a solar plate is underway as the use of solar plates in various devices continues to increase. Governing PDEs are first converted into ODEs using a suitable similarity transformation. The resulting higher-order coupled ODEs are converted into a system of first-order ODEs and then solved using the RK 4th-order method with shooting technique. The remarkable impacts of pertinent parameters such as Deborah number, magnetic field parameter, electric field parameter, Grashof number, solutal Grashof number, Prandtl number, Eckert number, exponential heat source parameter, Lewis number, chemical reaction parameter, bioconvection Lewis number, and Peclet number associated with the flow properties are discussed graphically. The increase in the radiation parameter and volume fraction of the nanoparticles enhances the temperature profile. The Bejan number and entropy generation rate increase with the rise in diffusion parameter and bioconvection diffusion parameter. The novelty of the present work is analyzing the entropy generation and solar radiation effects in the presence of motile gyrotactic microorganisms and copper nanoparticles with polyvinyl alcohol–water as the base fluid under the influence of the source terms, such as viscous dissipation, Ohmic heating, exponential heat source, and chemical reaction of the electromagnetohydrodynamic (EMHD) Jeffrey fluid flow. The non-Newtonian nanofluids have proven their great potential for heat transfer processes, which have various applications in cooling microchips, solar energy systems, and thermal energy technologies.

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Section: Introductionmentioning

confidence: 99%

Entropy Generation and Thermal Radiation Analysis of EMHD Jeffrey Nanofluid Flow: Applications in Solar Energy

et al. 2023

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“…Under the above assumptions and invoking the Boussinesq approximation, the governing equations for the flow are represented as ([ 34 , 48 ]):…”

Section: Mathematical Formulationmentioning

confidence: 99%

“…The density (

), heat capacity (

), electrical conductivity (

) and thermal expansion coefficient (

) of nanofluid are given by the usual relations as follows ([ 34 , 51 ]):

…”

Section: Mathematical Formulationmentioning

confidence: 99%

“…They considered the artery to be permeable as well as compliant. A mathematical model for medication delivery employing gold and alumina nanoparticles via a porous artery with stenosis was developed by Gandhi et al [ 34 ]. In their computational analysis through a curved stenosed permeable artery, Sharma et al [ 35 ] took into account the blood flow in two phases - the core and the plasma region, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Computer Simulations of EMHD Casson Nanofluid Flow of Blood through an Irregular Stenotic Permeable Artery: Application of Koo-Kleinstreuer-Li Correlations

et al. 2023

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A novel analysis of the electromagnetohydrodynamic (EMHD) non-Newtonian nanofluid blood flow incorporating CuO and Al2O3 nanoparticles through a permeable walled diseased artery having irregular stenosis and an aneurysm is analyzed in this paper. The non-Newtonian behavior of blood flow is addressed by the Casson fluid model. The effective viscosity and thermal conductivity of nanofluids are calculated using the Koo-Kleinstreuer-Li model, which takes into account the Brownian motion of nanoparticles. The mild stenosis approximation is employed to reduce the bi-directional flow of blood to uni-directional. The blood flow is influenced by an electric field along with a magnetic field perpendicular to the blood flow. The governing mathematical equations are solved using Crank-Nicolson finite difference approach. The model has been developed and validated by comparing the current results to previously published benchmarks that are peculiar to this study. The results are utilized to investigate the impact of physical factors on momentum diffusion and heat transfer. The Nusselt number escalates with increasing CuO nanoparticle diameter and diminishing the diameter of Al2O3 nanoparticles. The relative % variation in Nusselt number enhances with Magnetic number, whereas a declining trend is obtained for the electric field parameter. The present study’s findings may be helpful in the diagnosis of hemodynamic abnormalities and the fields of nano-hemodynamics, nano-pharmacology, drug delivery, tissue regeneration, wound healing, and blood purification systems.

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“…The mathematical expression for important hemodynamical factors such as wall shear stress, flow rate and resistive impedance are illustrated as 17 :…”

Section: Mathematical Formulationmentioning

confidence: 99%

Hall and ion slip effects on hybrid nanoparticles (Au-GO/blood) flow through a catheterized stenosed artery with thrombosis

Khanduri

Sharma

2022

Proceedings of the Institution of Mechanical Engineers, Part C:

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Present paper deals with the effect of Hall and ion slips on MHD blood flow through a catheterized multi-stenosis artery with thrombosis. Blood is considered a base fluid, and the suspension of Au and GO nanoparticles are used to form the hybrid nano-blood suspension. The hemodynamic mathematical model is presented to mimic the blood flow inside the artery subjected to Joule heating, thermal radiation, Hall and ion slip effects. The effect of the shape of nanoparticles and the variable viscosity depending upon hematocrit is taken into account. The mathematical model is presented in a curvilinear coordinate system, and a mild stenosis assumption is used to get the closed-form solutions. The reduced governing equations are solved using the Crank Nicholson scheme with “MATLAB.” The effect of various pertinent parameters on flow patterns are illustrated graphically. It is observed that increasing the Hall and ion slips parameter causes the increment in the fluid velocity due to an enhancement in the cyclotron frequency of the particles. The hybrid nanoparticles Au-GO/blood has a higher temperature profile than pure blood and unitary nanoparticles, as the thermal conductivity increases with an increase in nanoparticle concentration. Scientists and clinical researchers may find the present study useful in understanding the various illness’s conditions, including cancers, infections, and the removal of blood clots. Furthermore, current research may be helpful in the biomedical area, such as magnetic resonance angiography (MRA), which creates an image of an artery to identify any abnormalities in the artery. The current findings are consistent with recent findings in earlier blood flow research studies.

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Modeling and analysis of magnetic hybrid nanoparticle (Au-Al2O3/blood) based drug delivery through a bell-shaped occluded artery with joule heating, viscous dissipation and variable viscosity effects

Cited by 55 publications

References 53 publications

Entropy Generation and Thermal Radiation Analysis of EMHD Jeffrey Nanofluid Flow: Applications in Solar Energy

Entropy Generation and Thermal Radiation Analysis of EMHD Jeffrey Nanofluid Flow: Applications in Solar Energy

Computer Simulations of EMHD Casson Nanofluid Flow of Blood through an Irregular Stenotic Permeable Artery: Application of Koo-Kleinstreuer-Li Correlations

Hall and ion slip effects on hybrid nanoparticles (Au-GO/blood) flow through a catheterized stenosed artery with thrombosis

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