Modeling and Analysis of Radiation Therapy System with Respiratory Compensation Using Uppaal

Man, Ka Lok; Krilavičius, Tomas; Wan, Kaiyu; Hughes, Danny; Lee, Kevin

doi:10.1109/ispaw.2011.19

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Elekta HexaPOD TM evo RT System beam source, usually a medical linear accelerator (linac), tracking device, which provides information about the position of the patient and a controller that controls the treatment process. Several different control schemes have been proposed [37,38,39,27,7].…”

Section: Data Collectionmentioning

confidence: 99%

Predicting Respiratory Motion for Real-Time Tumour Tracking in Radiotherapy

Krilavičius

liobaite

Simonavičius³

et al. 2016

2016 IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS)

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Section: Data Collectionmentioning

confidence: 99%

Predicting Respiratory Motion for Real-Time Tumour Tracking in Radiotherapy

Krilavičius

liobaite

Simonavičius³

et al. 2016

2016 IEEE 29th International Symposium on Computer-Based Medical Systems (CBMS)

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“…automotive industry, 2 electronics, 3,4 industrial devices control, 5 medical devices control. [6][7][8] Process calculi are models or languages for concurrent and distributed interactive systems. They have also been used for modelling interactions in latency insensitive SoC interconnects.…”

Section: Introductionmentioning

confidence: 99%

Formal Modelling and Verification of Compensating Web Transactions

Das¹,

Chakraborty²,

Kapoor³

et al. 2013

IAENG Transactions on Electrical Engineering Volume 1

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Correctness of a system depends on the correct execution of transactions. For large systems, e.g., web-based, these transactions involve more than one component and hence more than one independent entity. Such transactions are called Long Running Transaction(LRT) as they coordinate complex interactions among multiple sub-systems. Well known roll-back mechanism do not suffice to handle faults in LRTs, therefore compensation mechanisms are introduced. However, introduced structures are complex and hard to understand and handle. Formal methods are well known tool for modelling, analysis and synthesis of complex systems. In this chapter we present a technique that allows modelling LRTs using Compensating CSP, then translating them to Promela language and analyzing using SPIN tool. We have modelled and verified the LRTs. We exemplify it using a web service called Air-ticket Reservation System (ATRS).

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“…Two different approaches to transforming a Petri net(Reisig, 2011) into Timed Automata are presented byNakano and Yamaguchi (2011), where also the important issue of state space explosion is addressed. Finally,Man et al (2011)…”

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confidence: 94%

Ab intra extraque: how the kinome regulates cell fate

Scholma

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Analysis of high throughput data and the unbiased interpretation of the data require novel ways of performing research. In this thesis we show novel methods for better quantification of multiplex array analysis of peptide phosphorylation. This quantification is necessary since, unlike the housekeeping gene expression used for the normalization and quantification of gene expression micro-arrays, housekeeping kinases that can be used for normalization and quantification are not present. In Chapter 2 therefore, we describe a novel method for normalization and quantification of data generated on a PepChip. Using this method we correct for signal gradients, artifacts, intensity distribution, intensity saturation and overshine from neighboring spots. Application of the resulting RSE (repetitive signal enhancement) protocol yielded better characterization of cellular physiology of drug treatment of cells from patients with myelodysplastic syndrome. Using this, we were able to better understand the signaling mechanisms dictating cell fate. An interesting observation when working with the PepChips was that the use of kinase substrates based on sequences derived from natural protein sequences, e.g. full-length proteins, protein fragments or short peptide sequences, often result in non-specific and insensitive kinase assays. Moreover, since there is a literature bias for the described kinase substrates, some kinases were underrepresented or overrepresented on the PepChip making kinome profiling based on natural kinase substrates quite impossible. We therefore show in Chapter 3 that it is possible to rationally design kinase peptide substrates that are both sensitive and selective for the desired kinase. We tested the sensitivity and selectivity of several designer peptides both in solution for measurement by mass spectrometry, as well as after immobilization of the peptides on a PepChip. The implication of this work is that we can now automatically design better kinome profiling PepChips by designing multiple selective and sensitive substrate peptides for a large part of the kinases in the kinome, resulting in unbiased kinome profiling for understanding cellular signal transduction networks. Intricate and complex signal transduction networks determine cell fate and malfunctioning networks underlie many diseases, including cancer, diabetes and osteoarthritis. Incomplete understanding of the network in References 1 Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225-236, doi:0092-8674(95)90405-0 [pii] (1995). 2 Cohen, P. Targeting protein kinases for the development of antiinflammatory drugs.

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Modeling and Analysis of Radiation Therapy System with Respiratory Compensation Using Uppaal

Cited by 6 publications

References 18 publications

Predicting Respiratory Motion for Real-Time Tumour Tracking in Radiotherapy

Predicting Respiratory Motion for Real-Time Tumour Tracking in Radiotherapy

Formal Modelling and Verification of Compensating Web Transactions

Ab intra extraque: how the kinome regulates cell fate

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