Modeling and simulation of an industrial‐scale parex process

Silva, Marta S. P.; Rodrigues, Alı́rio E.; Mota, José P. B.

doi:10.1002/aic.14732

Cited by 27 publications

(25 citation statements)

References 40 publications

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“…Calculation of operational parametersdinputs introduced by operators and outputs to process(Silva, 2013(Silva, , 2015. (Reprinted from AIChE Journal 61, Silva, M.S.P., Rodrigues, A.E., Mota, J.P.B., Modeling and simulation of an industrial-scale parex process, 1345e1363, Copyright (2015), with permission from John Wiley & Sons Inc.)…”

mentioning

confidence: 99%

The Parex Process for the Separation of p-Xylene

Rodrigues¹,

Pereira²,

Minceva³

et al. 2015

Simulated Moving Bed Technology

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mentioning

confidence: 99%

The Parex Process for the Separation of p-Xylene

Rodrigues¹,

Pereira²,

Minceva³

et al. 2015

Simulated Moving Bed Technology

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“…Two strategies can be, and have been, used to build the model of a SMB unit. One strategy is to mimic the real operation of the unit that periodically switches the positions of the inlet and outlet streams or the columns; the other strategy is based on an equivalent TMB model . The results obtained with the TMB model are close to the SMB model when the number of columns is large and the switching time and the column length are small enough …”

Section: Introductionmentioning

confidence: 83%

“…These considerations about the equivalence between the TMB and the SMB are valid when the dead volumes of the real SMB unit can be neglected or the dead volumes are uniformly distributed over the ring of columns and the system is operated under linear adsorption conditions. This is not the case for the Parex unit as it has different types of nonuniformly distributed dead volumes and is operated under overloaded, nonlinear conditions …”

Section: Introductionmentioning

confidence: 99%

Effect of dead volumes on the performance of an industrial‐scale simulated moving‐bed Parex unit for p‐xylene purification

2015

Self Cite

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The cyclic steady state (CSS) of the industrial-scale, seven-zone, simulated moving-bed (SMB) unit for p-xylene (p-x) purification (Parex unit) with three types of dead volumes-bed lines, push-around and pump-around circulation lines, and bed heads-is analyzed. In particular, the effects of the size and level of hydrodynamic dispersion of each dead volume on process performance and on its CSS are studied in detail. The circulation lines change the CSS behavior from t Ã -periodic to Nt Ã -periodic, where t Ã is the switching interval and N512 is the number of columns in each adsorbent chamber. A high level of axial dispersion in the bed lines, characterized by P eclet numbers smaller than 100, affects the p-x purity. Moreover, the bed lines lower the average p-x concentration in the extract, which reduces the p-x recovery. If the small time lags introduced by the circulation lines are neglected, it is possible to develop a detailed process model that considers the operation of the Parex unit over a single switching interval as opposed to a full cycle, and whose CSS solution can be efficiently computed using a full-discretization approach. Finally, it is shown that the volume of the bed heads influences significantly the performance of the Parex unit, and that its impact on the location of the operating point with respect to the boundaries of the separation region can be approximately taken into account using the standard true moving-bed-SMB equivalence rules if they are corrected for the presence of extra interparticle fluid.

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“…Powerful criteria to design processes with nonlinear isotherms (e.g., Langmuir and Bi-Langmuir) have been elaborated in the past few years (Charton & Nicoud, 1995;Mazzotti et al, 1997;Antos & Seidel-Morgenstern, 2001). Versatile results on triangle theory for the design of smb processes have been published (Nowak et al, 2012;Kim et al, 2016;Lim, 2004;Kazi et al, 2012;Bentley & Kawajiri, 2013;Bentley et al, 2014;Sreedhar et al, 2014;Toumi et al, 2007;Silva et al, 2015;Kiwala et al, 2016).…”

Section: Figure 1: Schematic Of Four-zone Smb Chromatographymentioning

confidence: 99%

Model-based process design of a ternary protein separation using multi-step gradient ion-exchange SMB chromatography

Lieres

Sun

et al. 2020

Computers & Chemical Engineering

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Model-based process design of ion-exchange simulated moving bed (iex-smb) chromatography for center-cut separation of proteins is studied. Use of nonlinear binding models that describe more accurate adsorption behaviours of macro-molecules could make it impossible to utilize triangle theory to obtain operating parameters. Moreover, triangle theory provides no rules to design salt profiles in iex-smb. In the modelling study here, proteins (i.e., ribonuclease, cytochrome and lysozyme) on the chromatographic columns packed with strong cation-exchanger SP Sepharose FF is used as an example system. The general rate model with steric mass-action kinetics was used; two closed-loop iex-smb network schemes were investigated (i.e., cascade and eight-zone schemes). Performance of the iex-smb schemes was examined with respect to multi-objective indicators (i.e., purity and yield) and productivity, and compared to a single column batch system with the same amount of resin utilized. A multi-objective sampling algorithm, Markov Chain Monte Carlo (mcmc), was used to generate samples for constructing the Pareto optimal fronts. mcmc serves on the sampling purpose, which is interested in sampling the Pareto optimal points as well as those near Pareto optimal. Pareto fronts of the three schemes provide the full information of trade-off between the conflicting indicators of purity and yield. The results indicate the cascade iex-smb scheme and the integrated eight-zone iex-smb scheme have the similar performance that both outperforms the single column batch system.

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Modeling and simulation of an industrial‐scale parex process

Cited by 27 publications

References 40 publications

The Parex Process for the Separation of p-Xylene

The Parex Process for the Separation of p-Xylene

Effect of dead volumes on the performance of an industrial‐scale simulated moving‐bed Parex unit for p‐xylene purification

Model-based process design of a ternary protein separation using multi-step gradient ion-exchange SMB chromatography

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