Modeling and simulation of deep brain stimulation electrodes with various active contacts

Sathi, Khaleda Akhter; Hosain, Md. Kamal

doi:10.1007/s42600-020-00060-0

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…A bipolar electrode configuration utilizes a pair of electrode contacts within its stimulation structure, one acting as negative contact and the other a positive one. A computational study has shown that in this case, the neurons respond differently from a simple linear combination of responses to the same two monopolar stimulation referenced to a distant ground [ 24 ], producing more complex activation zones [ 25 ]. Furthermore, a multi-electrode configuration having one current source and several surrounding return electrodes is believed to decrease the amount of current leakage to surrounding areas [ 26 ], suggesting specificity improvement with this multi-electrode configuration [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…A computational study has shown that in this case, the neurons respond differently from a simple linear combination of responses to the same two monopolar stimulation referenced to a distant ground [ 24 ], producing more complex activation zones [ 25 ]. Furthermore, a multi-electrode configuration having one current source and several surrounding return electrodes is believed to decrease the amount of current leakage to surrounding areas [ 26 ], suggesting specificity improvement with this multi-electrode configuration [ 24 ]. These computational studies reveal the current density distribution of different electrode configurations, which are relevant to the prediction of therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

et al. 2022

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Background Motor cortex stimulation applied as a clinical treatment for neuropathic disorders for decades. With stimulation electrodes placed directly on the cortical surface, this neuromodulation method provides higher spatial resolution than other non-invasive therapies. Yet, the therapeutic effects reported were not in conformity with different syndromes. One of the main issues is that the stimulation parameters are always determined by clinical experience. The lack of understanding about how the stimulation current propagates in the cortex and various stimulation parameters and configurations obstruct the development of this method. Methods In this study, we investigated the effect of different stimulation configurations on cortical responses to motor cortical stimulations using intrinsic optical imaging. Results Our results showed that the cortical activation of electrical stimulation is not only related to the current density but also related to the propagation distance. Besides, stimulation configurations also affect the propagation of the stimulation current. Conclusions All these results provide preliminary experimental evidence for parameter and electrode configuration optimizations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

et al. 2022

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“…[ 183 ] In addition, the conductivity of the surrounding medium significantly affects the distribution of electric fields in realistic head models. [ 184 ] Studying the biophysical models of the size and distribution of electric fields caused by intracranial electrode stimulation is crucial to understanding how the generated electric field modulates neuronal excitability, and is essential to the development of DBS technology. By conducting specialized biophysical studies on the size and distribution of electric fields caused by electrical stimulation and continuously iterating from clinical data, the model's accuracy can be significantly improved, ultimately accelerating the progress of DBS.…”

Section: Discussionmentioning

confidence: 99%

Flexible Electrodes for Brain–Computer Interface System

Wang

Liu

et al. 2023

Advanced Materials

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Brain‐computer interface (BCI) has been the subject of extensive research recently. Governments and companies have substantially invested in relevant research and applications. The restoration of communication and motor function, the treatment of psychological disorders, gaming, and other daily and therapeutic applications all benefit from BCI. The electrodes hold the key to the essential, fundamental BCI precondition of electrical brain activity detection and delivery. However, the traditional rigid electrodes are limited due to their mismatch in Young's modulus, potential damages to the human body and a decline in signal quality with time. These factors make the development of flexible electrodes vital and urgent. Flexible electrodes made of soft materials have grown in popularity in recent years as an alternative to conventional rigid electrodes because they offer greater conformance, the potential for higher signal‐to‐noise ratio (SNR) signals, and a wider range of applications. Therefore, the latest classifications and future developmental directions of fabricating these flexible electrodes are explored in this paper to further encourage the speedy advent of flexible electrodes for BCI. In summary, the perspectives and future outlook for this developing discipline are provided.This article is protected by copyright. All rights reserved

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“…Electric field distribution changes for different electrode placements. When the distribution was modeled for various active contacts to optimize therapeutic effect, tripolar electrode configuration provided the highest concentrated electric field distribution and sufficient current density compared to monopolar, bipolar, and quadripolar configurations 30 …”

Section: Current Issues With Dbsmentioning

confidence: 99%

Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions

Kolaya

Firestein

2021

Biotechnology Progress

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Deep brain stimulation (DBS) is used to treat the motor symptoms of Parkinson's disease patients by stimulating the subthalamic nucleus. However, optimization of DBS is still needed since the performance of the neural electrodes is limited by the body's response to the implant. This review discusses the issues with DBS, such as placement of electrodes, foreign body response, and electrode degradation. The current solutions to these technical issues include modifications to electrode material, coatings, and geometry.

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Modeling and simulation of deep brain stimulation electrodes with various active contacts

Cited by 8 publications

References 27 publications

Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

Impacts of stimulus parameters and configurations on motor cortex direct electrical stimulation using intrinsic optical imaging: a pilot study

Flexible Electrodes for Brain–Computer Interface System

Deep brain stimulation: Challenges at the tissue‐electrode interface and current solutions

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