2020
DOI: 10.3233/thc-209003
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Modeling and simulation of excitation- contraction coupling of fast-twitch skeletal muscle fibers

Abstract: BACKGROUND: The current excitation-contraction coupling model of fast-twitch skeletal muscle fibers cannot completely simulate the excitation-contraction process. OBJECTIVE: To solve this problem, this study proposes an excitation-contraction model of fast-twitch skeletal muscle fibers based on the physiological structure and contractile properties of half-sarcomeres. METHODS: The model includes the action potential model of fast-twitch fiber membranes and transverse tubule membranes, the cycle model of Ca 2+ … Show more

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Cited by 2 publications
(1 citation statement)
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“…Preceding models addressed ECC in one or two fiber types, mainly as most previous functional and biochemical information came from a dichotomic approach of muscle fibers: either slow vs. fast, or type I vs. type II [13,14,16,[34][35][36][37]. Additionally, simulations that have recently become spatially and mathematically more complex have remained biochemically oversimplified [38,39]. By taking Ca 2+ transients obtained in molecularly typed fibers covering the whole spectra from I to IIB as experimental source, our model adds novel information on the ECC-fiber type relationships.…”
Section: A Model Which Includes Four Fiber Typesmentioning
confidence: 99%
“…Preceding models addressed ECC in one or two fiber types, mainly as most previous functional and biochemical information came from a dichotomic approach of muscle fibers: either slow vs. fast, or type I vs. type II [13,14,16,[34][35][36][37]. Additionally, simulations that have recently become spatially and mathematically more complex have remained biochemically oversimplified [38,39]. By taking Ca 2+ transients obtained in molecularly typed fibers covering the whole spectra from I to IIB as experimental source, our model adds novel information on the ECC-fiber type relationships.…”
Section: A Model Which Includes Four Fiber Typesmentioning
confidence: 99%