2016
DOI: 10.1371/journal.pcbi.1004872
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Modeling and Simulation of Mucus Flow in Human Bronchial Epithelial Cell Cultures – Part I: Idealized Axisymmetric Swirling Flow

Abstract: A multi-mode nonlinear constitutive model for mucus is constructed directly from micro- and macro-rheology experimental data on cell culture mucus, and a numerical algorithm is developed for the culture geometry and idealized cilia driving conditions. This study investigates the roles that mucus rheology, wall effects, and HBE culture geometry play in the development of flow profiles and the shape of the air-mucus interface. Simulations show that viscoelasticity captures normal stress generation in shear leadi… Show more

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Cited by 34 publications
(40 citation statements)
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“…Multiscale analyses of ciliated tissues not only reveal new tissue-level phenomena, but also enable a quantification of their functional roles in different tissue environments. Such analyses require the integration of empirical and computational approaches for studying cilia function, like those developed in this study, as well as for investigating the particular fluid environment, including air and mucus (47).…”
Section: Discussionmentioning
confidence: 99%
“…Multiscale analyses of ciliated tissues not only reveal new tissue-level phenomena, but also enable a quantification of their functional roles in different tissue environments. Such analyses require the integration of empirical and computational approaches for studying cilia function, like those developed in this study, as well as for investigating the particular fluid environment, including air and mucus (47).…”
Section: Discussionmentioning
confidence: 99%
“…It is usually modeled as a Newtonian fluid. In modeling the ASL, some studies focus on the PCL layer, the mucus layer or both [35][36][37][38]. Different modeling strategies have been devised by researchers working to capture the complex dynamics of mucociliary clearance.…”
Section: Introductionmentioning
confidence: 99%
“…Different modeling strategies have been devised by researchers working to capture the complex dynamics of mucociliary clearance. These models differ mainly in their description of the mucus behavior, some describe the mucus as a Newtonian fluid [35,36,[39][40][41] while others describe it as a non-Newtonian fluid [37,38,[42][43][44][45]. These different models have their perks but they also have limitations, great strides have been made toward modeling mucociliary clearance and it remains an active area of research.…”
Section: Introductionmentioning
confidence: 99%
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