As unmanned vehicles become smaller and more autonomous, it is becoming feasible to use them in large groups with comparatively few human operators. Design and analysis of such distributed systems are complicated by the many interactions among agents and phenomena of human behavior. In particular, human susceptibility to fatigue and cognitive overload can introduce errors and uncertainty into the system. In this paper, we demonstrate how advanced computational tools can help to overcome these engineering difficulties by optimizing multirobot, multioperator surveillance systems for cost, speed, accuracy, and stealth according to diverse user preferences in multiple case studies. The tool developed is a graphical user interface that returns the optimal number and mix of diverse agent types as a function of the user's trade‐off preferences. System performance prediction relies on a multiagent simulation with submodels for human operators, fixed‐wing unmanned aerial vehicles (UAVs), quadrotor UAVs, and flapping wing UAVs combined in different numbers.