Modeling and Simulation of Skeletal Muscle Based on Metabolism Physiology

Abstract

Skeletal muscle energy metabolism plays a very important role in controlling movement of the whole body and has important theoretical guidance for making exercise training plans and losing weight. In this paper, we developed a mathematical model of skeletal muscle excitation–contraction pathway based on the energy metabolism that links excitation to contraction to explore the effects of different metabolic energy systems on calcium ion changes and the force during skeletal muscle contraction. In this paper, a membrane potential model, a calcium cycle model, a cross-bridge dynamics model and an energy metabolism model were established. Finally, the physiological phenomenon of calcium ion transport and calcium ion concentration change of the sarcoplasm was simulated. The results show that the phosphagen system has the fastest metabolic rate and the phosphagen system has the largest impact on the explosive power of skeletal muscle exercise. The specific characteristics of the three metabolic energy systems supporting skeletal muscle movement in vivo were also analyzed in detail.

Computational Model of the Effect of Mitochondrial Dysfunction on Excitation–Contraction Coupling in Skeletal Muscle

“… 2018 ). A more recent model of ECC incorporating mitochondrial metabolism was used to explore the impact of metabolic energy systems on crossbridge cycling (Wang et al 2020 ); however, the link between calcium and OXPHOS was still missing.…”