Self-Compacting Concrete (SCC) is a special concrete that can flow easily across congested reinforcements. Also, it is easy to work with and does not segregate. The present investigation aims at the design and development of sustainable SCC with the employment of industrial by-products such as Fly Ash (FA), Ground Granulated Blast Furnace Slag (GGBFS), and Expanded Perlite Aggregate (EPA). Four SCC mixes were developed to attain a target strength of 30 MPa. Workability tests (slump flow, J-ring, and V-funnel tests) were performed following the EFNARC guidelines to ensure fresh SCC properties. Detailed experiments were conducted to evaluate the durability characteristics of the developed SCC, such as water absorption, sorptivity, acid attacks (sulphuric, nitric, sulphate, and chloride), the Rapid Chloride Penetration Test (RCPT), and finally, the elevated temperature test. Weight loss, strength loss, and physical observations of the acid and temperature effects of SCC mixes were evaluated. Also, the study focuses on the cost and sustainable index of SCC mixes and compares them with OPC mixes. From the experimental data analysis, it was observed that the developed SCC showed excellent physical and mechanical properties with a considerable reduction in cement content. SCC specimens with FA and EPA exhibit excellent acid and temperature resistance. Following the sustainable analysis, it was noted that SCC mixes reduce about 15–17.2% of carbon emissions compared to the OPC mix.