Modeling microstructure of incudostapedial joint and the effect on cochlear input

Gan, Rong Z.; Wang, Xuelin

doi:10.1063/1.4939366

Cited by 7 publications

(9 citation statements)

References 12 publications

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“…As can be seen in Figure 8A, increasing the Young's modulus to 6 MPa did change the overall stapes velocity, but replacing the interior with a fluid did not alter the ME response further for our model. The ME model by Gan and Wang (2014) contained more microstructural details in the ISJ, such as articular cartilage and a meniscus, and their results suggested that modeling the synovial nature of the joint improves the match with experimental data and is therefore influential for ME transmission.…”

Section: Incudostapedial Joint Microstructurementioning

confidence: 99%

“…The densities of the ossicles were 2390 kg/m 3 (malleus), 2150 kg/m 3 (incus), and 2200 kg/m 3 (stapes) (Homma et al, 2009). The interior of the ISJ in reality encapsulates articular cartilage on both articular surfaces, synovial fluid, and a meniscus, as modelled in detail by Gan and Wang (2014). However, these components are too small to distinguish the different materials on our µCT images, so as an approximation the entire interior was modeled as a fluid, with a bulk modulus of 2.2 GPa (as used in Zhang and Gan (2011b) and Gan and Wang (2014)) and mass density of 1200 kg/m 3 .…”

Section: Materials Parameters Of the Base Modelsmentioning

confidence: 99%

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Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics

2017

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The presented results provide insights into the importance of different features in middle ear finite element modeling. The application of three different individual middle ear geometries in a single study reduces the possibility that the conclusions are strongly affected by geometrical abnormalities. Some modeling variations that were hypothesized to be influential turned out to be of minor importance. Furthermore, it could be confirmed that different geometries, simulated using the same parameters and definitions, can produce significantly different responses.

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Section: Incudostapedial Joint Microstructurementioning

confidence: 99%

Section: Materials Parameters Of the Base Modelsmentioning

confidence: 99%

Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics

2017

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“…Knowledge on ME morphology is especially relevant for two otologic fields of study. First, it is important for the construction of highly realistic finite element models (FE models) of ME mechanics, a research branch that is very popular in the field (Funnell and Laszlo, ; Funnell and Medical, ; Williams and Lesser, ; Wada et al, ; Kelly et al, ; Fay et al, ; Gan et al, ; Wang et al, ; Hoffstetter et al, ; Gentil et al, ; Volandri et al, ; Gentil et al, ; Aernouts et al, ; Böhnke et al, ; Muyshondt et al, ; De Greef et al, ; Gan and Wang, ). Second, new data and statistical knowledge about these structures are of direct relevance to the field of otologic surgery, for example, for surgical interventions or for the implantation of hearing aids.…”

Section: Introductionmentioning

confidence: 99%

Details of human middle ear morphology based on micro‐CT imaging of phosphotungstic acid stained samples

Greef

Buytaert

Aerts

et al. 2015

Journal of Morphology

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A multitude of morphological aspects of the human middle ear (ME) were studied qualitatively and/or quantitatively through the postprocessing and interpretation of micro-CT (micro X-ray computed tomography) data of six human temporal bones. The samples were scanned after phosphotungstic acid staining to enhance soft-tissue contrast. The influence of this staining on ME ossicle configuration was shown to be insignificant. Through postprocessing, the image data were converted into surface models, after which the approaches diverged depending on the topics of interest. The studied topics were: the ME ligaments; morphometric and mechanical parameters of the ossicles relating to inertia and the ossicular lever arm ratio; the morphology of the distal incus; the contact surface areas of the tympanic membrane (TM) and of the stapes footplate; and the thickness of the TM, round window of the cochlea, ossicle joint spaces, and stapedial annular ligament. Some of the resulting insights are relevant in ongoing discussions concerning ME morphology and mechanical functions, while other results provide quantitative data to add to existing data. All findings are discussed in the light of other published data and many are relevant for the construction of mechanical finite element simulations of the ME.

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“…FE models are sensitive to both the geometry used to define them and to the mechanical properties (e.g. Young's modulus and Poisson's ratio) assigned to simulate their components (Gan & Wang, 2015; Soleimani et al ., 2017). Unfortunately, current FE models use grossly oversimplified geometry to represent the ISJ, consisting of blocks or concentric cylindrical elements, due to the paucity of accurate anatomic data.…”

Section: Introductionmentioning

confidence: 99%

“…Tel: +1(519) 661-2111 × 85507; fax: +1(519) 661-2123; e-mail: srohani4@uwo.ca to the cochlea, the end organ of hearing. The incudostapedial joint (ISJ) connecting the incus and stapes in the middle ear significantly affects sound transmission to the cochlea (Funnell et al, 2005;Zhang & Gan, 2011;Gan & Wang, 2015;Soleimani et al, 2016;Soleimani et al, 2017). Pathologies such as disarticulation and ankyloses of the joint are common and may cause hearing loss when vibrations can no longer be efficiently transmitted (Sim & Chang, 2008;Suzuki et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

High‐resolution imaging of the human incudostapedial joint using synchrotron‐radiation phase‐contrast imaging

Rohani

Allen

Gare

et al. 2020

Journal of Microscopy

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Summary The incudostapedial joint (ISJ) of the middle ear is important for proper transmission of sound energy to the cochlea. Recently, the biomechanics of the ISJ have been investigated using finite‐element (FE) modelling, using simplified geometry. The objective of the present study was to investigate the feasibility of synchrotron‐radiation phase‐contrast imaging (SR‐PCI) in visualising the ISJ ultrastructure. Three human cadaveric ISJs were dissected and scanned using SR‐PCI at 0.9 µm isotropic voxel size. One of the samples was previously scanned at 9 µm voxel size. The images were visually compared and contrast‐to‐noise ratios (CNRs) were calculated (of both bone and soft tissues) for quantitative comparisons. The ISJ ultrastructure as well as adjacent bone and soft tissues were clearly visible in images with a 0.9 µm voxel size. The CNRs of the 0.9 µm images were relatively lower than those of the 9 µm scans, while the ratio of bone to soft tissue CNRs were higher, indicating better discernibility of bone from soft tissue in the 0.9 µm scans. This study was the first known attempt to image the ISJ ultrastructure using an SR‐PCI scanner at submicron voxel size and results suggest that this method was successful. Future studies are needed to optimise the contrast and test the feasibility of imaging the ISJ in situ. Lay Description The human middle ear consists of the eardrum, three small bones (the malleus, incus and stapes) and two joints connecting the bones (the incudostapedial joint and the incudomallear joint). The role of the middle ear is to amplify and transfer sound energy to the cochlea, the end organ of hearing. The incudostapedial joint (ISJ) of the middle ear is a synovial joint which is important for proper transmission of sound energy to the cochlea. Similar to other synovial joints it consists of meniscus, fluid and articulating surfaces. Recently, the biomechanics of the ISJ have been investigated using computational models, using grossly simplified geometry. Synchrotron radiation phase contrast imaging (SR‐PCI) is a high‐resolution imaging technique used to visualise small structures in three dimensions. The objective of the present study was to investigate the feasibility of using SR‐PCI in visualising the ISJ ultrastructure. Three human cadaveric ISJs were dissected and scanned using SR‐PCI at 0.9 µm isotropic voxel size. One of the samples was previously scanned at 9 µm voxel size. The images were both qualitatively and quantitatively compared. This study was the first known attempt to image the ISJ ultrastructure using an SR‐PCI scanner at submicron voxel size and results suggest that this method was successful. Future studies are needed to optimise the contrast and feasibility of imaging the ISJ in situ.

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Modeling microstructure of incudostapedial joint and the effect on cochlear input

Cited by 7 publications

References 12 publications

Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics

Effects of model definitions and parameter values in finite element modeling of human middle ear mechanics

Details of human middle ear morphology based on micro‐CT imaging of phosphotungstic acid stained samples

High‐resolution imaging of the human incudostapedial joint using synchrotron‐radiation phase‐contrast imaging

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