Modeling normal tissue complication probability from repetitive computed tomography scans during fractionated high-dose-rate brachytherapy and external beam radiotherapy of the uterine cervix

Uterusnekrose nach Radiochemotherapie lokal fortgeschrittener Zervixkarzinome

“…The model of normal tissue complication probability (NTCP) was introduced in 1991 by Burman et al [1] and has been performed in external-beam radiotherapy only. Dale et al [3] presented a method of calculating NTCPs for external-beam radiotherapy and HDR brachytherapy. However, for demonstrating reliable data, three to four CT scans are needed.…”

“…Brachytherapy with 3-D planning, contouring of the organs at risk, calculation of dose-volume histograms, and systematic application of the NTCP models in clinical routine may increase the safety of radiation therapy [3].…”

Evaluation of a new method for calculation of cumulative doses in the rectum wall using repeat ct scans

“…Cumulative doses were also found using a method proposed by Dale et al (1). Because of the left Á/right symmetry in the body and the beam configurations, they assumed that it is the same volume of the rectum that receives the high dose in all fractions (and the same volume that receives the low dose).…”

Investigation of whether in-room CT-based adaptive intracavitary brachytherapy for uterine cervical cancer is robust against interfractional location variations of organs and/or applicators

“…The fitting parameter values n, m and ${\mathrm{TD}}_{50}true(v_{\mathrm{ref}}true)$ were set at 0.13, 0.11 and 90 Gy for the bladder, and at 0.06, 0.15 and 75 Gy for the rectum, respectively; these values were obtained from the report of Burman et al . [25, 28]. …”