Modeling of closed-loop recycling liquid–liquid chromatography: Analytical solutions and model analysis

Kostanyan, A. E.

doi:10.1016/j.chroma.2015.06.010

Cited by 25 publications

(4 citation statements)

References 33 publications

(63 reference statements)

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“…For the modeling and design of the CLR CCC separations, two approaches can be used [134,135]: the ideal recycling mode and the non-ideal recycling mode. The first approach ( Figure 4) can be used when the volume of the recycling system (connecting lines, pump, detector, and valves) does not exceed one percent of the column volume.…”

Section: Closed-loop Recycling CCC Separationsmentioning

confidence: 99%

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

2020

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Countercurrent liquid-liquid chromatographic techniques (CCC), similar to solvent extraction, are based on the different distribution of compounds between two immiscible liquids and have been most widely used in natural product separations. Due to its high load capacity, low solvent consumption, the diversity of separation methods, and easy scale-up, CCC provides an attractive tool to obtain pure compounds in the analytical, preparative, and industrial-scale separations. This review focuses on the steady-state and non-steady-state CCC separations ranging from conventional CCC to more novel methods such as different modifications of dual mode, closed-loop recycling, and closed-loop recycling dual modes. The design and modeling of various embodiments of CCC separation processes have been described.

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Section: Closed-loop Recycling CCC Separationsmentioning

confidence: 99%

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

2020

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“…Longitudinal mixing rates in two phases could be measured by several sets of experimental data, and then the distribution behavior of other compounds with providing K D values could be predicted [81]. Analytical equations for different operating modes were derived after some reasonable conversions to further enrich the studies of the longitudinal dispersion in internal dynamics [82,83]. Besides, the effects of flow rate and rotational speed on axial diffusion rate were also studied [84].…”

Section: Modeling the Dynamic Process Of Counter‐current Chromatographymentioning

confidence: 99%

Recent progress in separation prediction of counter‐current chromatography

Guo

Tong

Zhang

et al. 2020

J of Separation Science

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As a liquid‐liquid partition chromatography, counter‐current chromatography has advantages in large sample loading capacity without irreversible adsorption, which has been widely applied in separation and purification fields. The main factors, including partition coefficient, two‐phase solvent systems, apparatus, and operating parameters greatly affect the separation process of counter‐current chromatography. To promote the applications of counter‐current chromatography, it is essential to develop theoretical research to master the principles of counter‐current chromatographic separations so as to achieve predictions before laborious trials. In this article, recent progress about separation prediction methods are reviewed from a point of the steady and unsteady state of the mass transfer process of counter‐current chromatography and its mass transfer characteristics, and then it is divided into three aspects: prediction of partition coefficient, modeling the thermodynamic process of counter‐current chromatography, and modeling the dynamic process of counter‐current chromatography.

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“…The use of large amounts of mixed organic solvents in LLC is usually associated with difficulties in the recycling of solvents [ 10 ] and the release of volatile organic compounds (VOCs) [ 11 ]. The option of solvent recycling [ 12 ] allows the reuse of the column effluent, but the full separation of effluents into single solvent components is a cumbersome and expensive process due to the similarity in boiling points of individual components (with potential azeotrope formation in some cases) [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

Brown¹,

Earle

Gîlea

et al. 2017

Top Curr Chem (Z)

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Ionic liquids can form biphasic solvent systems with many organic solvents and water, and these solvent systems can be used in liquid–liquid separations and countercurrent chromatography. The wide range of ionic liquids that can by synthesised, with specifically tailored properties, represents a new philosophy for the separation of organic, inorganic and bio-based materials. A customised countercurrent chromatograph has been designed and constructed specifically to allow the more viscous character of ionic liquid-based solvent systems to be used in a wide variety of separations (including transition metal salts, arenes, alkenes, alkanes, bio-oils and sugars).

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Modeling of closed-loop recycling liquid–liquid chromatography: Analytical solutions and model analysis

Cited by 25 publications

References 33 publications

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

Recent progress in separation prediction of counter‐current chromatography

Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

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