Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

Brown, Leslie; Earle, Martyn J.; Gîlea, Manuela A.; Plechkova, Natalia V.; Seddon, Kenneth R.

doi:10.1007/s41061-017-0159-y

Cited by 27 publications

(8 citation statements)

References 169 publications

(169 reference statements)

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“…91 As a final example, ILs also support important developments in analytics technologies, e.g. the development of new gas chromatography columns with stationary phases based on ILs (some of which are now commercially available) 92 and new ionic liquid−liquid chromatography methods 93 that are currently under development with a commercial partner.…”

Section: Impacts Of Il Structure During the Application Stagementioning

confidence: 99%

Toward the Proactive Design of Sustainable Chemicals: Ionic Liquids as a Prime Example

et al. 2021

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The tailorable and often unique properties of ionic liquids (ILs) drive their implementation into a broad variety of seminal technologies. The modular design of ILs allows in this context a proactive selection of structures that favor environmental sustainabilityideally without compromising their technological performance. To achieve this objective, the whole life cycle must be taken into account and various aspects considered simultaneously. In this review, we discuss how the structural design of ILs affects their environmental impacts throughout all stages of their life cycles and scrutinize the available data in order to point out knowledge gaps that need further research activities. The design of more sustainable ILs starts with the selection of the most beneficial precursors and synthesis routes, takes their technical properties and application specific performance into due account, and considers its environmental fate particularly in terms of their (eco)toxicity, biotic and abiotic degradability, mobility, and bioaccumulation potential. Special emphasis is placed on reported structure−activity relationships and suggested mechanisms on a molecular level that might rationalize the empirically found design criteria.

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Section: Impacts Of Il Structure During the Application Stagementioning

confidence: 99%

Toward the Proactive Design of Sustainable Chemicals: Ionic Liquids as a Prime Example

et al. 2021

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“…Conventional room temperature ionic liquids (ILs) have been extensively studied starting from the beginning of this century by several authors due to their unique physico-chemical properties, which have allowed for their use in numerous applications (Welton, 2018). Low vapor pressure and high thermal stability, associated with possible catalytic actions, which emerge in particular when properly functionalized cations or anions were used (Chiappe and Pomelli, 2014), contributed to their application as innovative green solvents for a plethora of important processes going from (bio)polymer dissolution (Shen et al, 2016; Mezzetta et al, 2017a; Zhang et al, 2017), to chemical reactions (Hallett and Welton, 2011) and separations (Brown et al, 2017). Furthermore, the wide electrochemical window and the high conductivity enabled their use as electrolytes in solar cells and batteries (Watanabe et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Systematic Synthesis and Properties Evaluation of Dicationic Ionic Liquids, and a Glance Into a Potential New Field

et al. 2018

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Dicationic ionic liquids (DILs), a subset of the ionic liquid (IL) family, have attracted growing interest in recent years, and the range of applications within which they are investigated is constantly expanding. However, data which allows structure to property correlation of a DIL is still limited, and thus selecting an appropriate salt to address a specific challenge can be problematic. In comparison to traditional ILs, DILs physico-chemical properties can be tuned by changing the length and type of spacer which connects the cationic heads as well as the type of cation. This in turn could give rise to symmetrical or asymmetrical DILs. In this work, a systematic study of a homogeneous class of 12 dibromide DILs and 12 di-carboxylate salts has been performed. The latter class of DILs were also compared to mono cation derivatives. The different traditional exchange methods to prepare carboxylate DILs have been evaluated and an insight into the drawbacks encountered is also presented. Prepared DILs were characterized (NMR, TGA, DSC) allowing the influence of the structure on their thermal stability to be understood. Most DILs were obtained as solid salts after careful drying. For some of these compounds, a new possible application was studied, namely their use as hydrogen bond acceptors (HBA) of deep eutectic mixtures, showing again some significant structural related effects.

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“…Ionic liquid can form biphasic solvent systems with many organic solvents and water, and these systems can be used in liquid‐liquid separation, counter current chromatography . Extraction process for Nizatidine, was done by taking 1 mL ionic liquid i.e., 1‐butyl‐3‐methylimidazolium hexa fluoro phosphate and was transferred into a 10 mL centrifuge tube.…”

Section: Sample Preparationmentioning

confidence: 99%

Analytical techniques for Nizatidine: A review

Rathore

Doijode

et al. 2019

Separation Science Plus

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Nizatidine is a histamine H2 receptor antagonist. This compound belongs to the class of organic compounds known as 2,4‐di‐substituted thiazoles. These are the compounds containing a thiazole ring. It inhibits the action of histamine mediated by H2 receptors such as gastric acid and pepsin output and the drug is used for the treatment of duodenal ulcers. This review presents an overview about the different analytical methods for the analysis of Nizatidine and its metabolite in biological fluids, commercial products, and simultaneous estimation of other H2 receptor antagonist in commercial products. The most commonly used analytical method for Nizatidine is high‐performance liquid chromatography. This review also gives information about pharmacokinetics, its application and susceptibility of H2 receptor antagonist to metabolism by gastrointestinal flora.

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Ionic Liquid–Liquid Chromatography: A New General Purpose Separation Methodology

Cited by 27 publications

References 169 publications

Toward the Proactive Design of Sustainable Chemicals: Ionic Liquids as a Prime Example

Toward the Proactive Design of Sustainable Chemicals: Ionic Liquids as a Prime Example

Systematic Synthesis and Properties Evaluation of Dicationic Ionic Liquids, and a Glance Into a Potential New Field

Analytical techniques for Nizatidine: A review

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