Cooperation across organisational boundaries is increasing. When such cooperation moves beyond the trade of well-defined products, there is a need for a flexible infrastructure that supports not only information exchange, but also knowledge creation, sharing, utilisation and learning. Active models constitute a general technique for increasing the flexibility of computerised information systems. Such models are available for manipulation by the users at runtime, and the model contents influence the behaviour ofthe system. By altering the models, the users can thus tailor the system to fit their particular needs and preferences. This paper explores the use of active models to support digitally enabled creative business networks. In particular, we look at how enterprise and work process models can support virtual enterprise formation, engineering, operation, and learning. Our initial results indicate the great potential of active models in this area.